Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe.
Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe.
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DOI：
10.1186/s12917-017-1266-2
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发表时间：
2017-11-17
影响因子：
2.6
通讯作者：
Gyuranecz M
中科院分区：
文献类型：
--
作者：
Kreizinger Z;Grózner D;Sulyok KM;Nilsson K;Hrivnák V;Benčina D;Gyuranecz M
滑膜支原体可引起鸡和火鸡的感染性滑膜炎和呼吸道疾病，并可导致鸡的蛋壳顶端异常，因此对养殖业具有很高的经济影响。疾病的控制包括根除、接种疫苗或药物治疗。本研究的目的是确定来自匈牙利和中东欧其他国家的滑膜支原体对14种不同抗生素和一种抗生素组合的体外敏感性。用微量肉汤稀释法测定了41株滑膜分枝杆菌的最低抑菌浓度(MIC)。这些毒株是在2002年至2016年期间收集的，来自匈牙利(n = 26)、奥地利(n = 3)、捷克共和国(n = 3)、斯洛文尼亚(n = 3)、乌克兰(n = 3)、俄罗斯(n = 2)和塞尔维亚(n = 1)。四环素类药物(多西环素、土霉素和金霉素的MIC50值分别为0.078μg/ml、≤0.25μg/ml和0.5μg/ml)、大环内酯类药物(对泰华菌素、泰乐菌素和替米考星的MIC50值分别为≤0.25μg/ml)、胸膜多菌素类药物(对硫菌灵和万乃近的MIC50值分别为0.078μg/ml和≤0.039μg/ml)以及林可霉素和壮观霉素的联合用药(MIC50为0.333/0.667μg/ml)是最有效的体外抗菌药物。对氟喹诺酮类药物(恩诺沙星和地氟沙星的MIC50值分别为1.2 5μg/ml和2.5μg/ml)、新霉素(MIC5 0 32μg/ml)、壮观霉素(MIC5 0 2μg/ml)、林可霉素(MIC5 0 0.5μg/ml)和氟苯尼考(MIC5 0 0μg/ml)均有较高的MIC值。然而，大多数应用的抗生素都检测到了MIC值升高的菌株。在滑膜分枝杆菌感染的医学控制中，初步的体外药敏试验和仔细的数据评估是至关重要的。多西环素、土霉素、霉菌素、泰乐菌素和胸膜多柔比星可推荐用于该地区滑膜分枝杆菌感染的治疗。本文的在线版本(10.1186/s12917-017-1266-2)包含补充材料，可供授权用户使用。
Mycoplasma synoviae causes infectious synovitis and respiratory diseases in chickens and turkeys and may lead to egg shell apex abnormalities in chickens; hence possesses high economic impact on the poultry industry. Control of the disease consists of eradication, vaccination or medication. The aim of the present study was to determine the in vitro susceptibility to 14 different antibiotics and an antibiotic combination of M. synoviae strains originating from Hungary and other countries of Central and Eastern Europe. Minimal inhibitory concentration (MIC) values of a total of 41 M. synoviae strains were determined by the microbroth dilution method. The strains were collected between 2002 and 2016 and originated from Hungary (n = 26), Austria (n = 3), the Czech Republic (n = 3), Slovenia (n = 3), Ukraine (n = 3), Russia (n = 2) and Serbia (n = 1). Tetracyclines (with MIC50 values of 0.078 μg/ml, ≤0.25 μg/ml and 0.5 μg/ml for doxycycline, oxytetracycline and chlortetracycline, respectively), macrolides (with MIC50 values of ≤0.25 μg/ml for tylvalosin, tylosin and tilmicosin), pleuromutilins (with MIC50 values of 0.078 μg/ml and ≤0.039 μg/ml for tiamulin and valnemulin) and the combination of lincomycin and spectinomycin (MIC50 1 μg/ml (0.333/0.667 μg/ml)) were found to be the most effective antibiotic agents against M. synoviae in vitro. High MIC values were detected in numerous strains for fluoroquinolones (with MIC50 values of 1.25 μg/ml and 2.5 μg/ml for enrofloxacin and difloxacin), neomycin (MIC50 32 μg/ml), spectinomycin (MIC50 2 μg/ml), lincomycin (MIC50 0.5 μg/ml) and florfenicol (MIC50 4 μg/ml). Nevertheless, strains with elevated MIC values were detected for most of the applied antibiotics. In the medical control of M. synoviae infections the preliminary in vitro antibiotic susceptibility testing and the careful evaluation of the data are crucial. Based on the in vitro examinations doxycycline, oxytetracycline, tylvalosin, tylosin and pleuromutilins could be recommended for the therapy of M. synoviae infections in the region. The online version of this article (10.1186/s12917-017-1266-2) contains supplementary material, which is available to authorized users.
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