Functional connectivity in the retina at the resolution of photoreceptors.
Functional connectivity in the retina at the resolution of photoreceptors.
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要理解神经回路，需要知道它的连通性。本文报告了在单细胞分辨率下测量视网膜输入层和输出层之间的功能连接性及其对色觉的影响。多电极技术被用来同时记录将高分辨率视觉信号传输到大脑的视网膜神经节细胞类型(侏儒、阳伞、小双层)的完整群体。用细粒视觉刺激来确定每个视锥感光感受器到每个神经节细胞的功能输入的位置、类型和强度。打开和关闭的侏儒细胞和遮阳伞细胞的种群都对长波长和中波长敏感视锥的完整种群进行了采样。然而，只有非侏儒细胞频繁地接受来自短波敏感视锥的强输入。开和关的侏儒细胞表现出一种小的非随机倾向，选择性地从长波长或中波长敏感的锥体中取样，这种倾向的程度不能用锥体镶嵌中的块状来解释。这些测量揭示了神经电路中单个神经元的基本分辨率的计算。
To understand a neural circuit requires knowing its connectivity. This paper reports measurements of functional connectivity between the input and ouput layers of the retina at single cell resolution and its implications for color vision. Multi-electrode technology was employed to record simultaneously from complete populations of the retinal ganglion cell types (midget, parasol, small bistratified) that transmit high-resolution visual signals to the brain. Fine-grained visual stimulation was used to identify the location, type and strength of the functional input of each cone photoreceptor to each ganglion cell. The populations of ON and OFF midget and parasol cells each sampled the complete population of long and middle wavelength sensitive cones. However, only OFF midget cells frequently received strong input from short wavelength sensitive cones. ON and OFF midget cells exhibited a small non-random tendency to selectively sample from either long or middle wavelength sensitive cones, to a degree not explained by clumping in the cone mosaic. These measurements reveal computations in a neural circuit at the elementary resolution of individual neurons.
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影响因子：
5.5
作者：
KAISER, PK;LEE, BB;VALBERG, A
通讯作者：
VALBERG, A
影响因子：
5.5
作者：
BAYLOR, DA;NUNN, BJ;SCHNAPF, JL
通讯作者：
SCHNAPF, JL
影响因子：
64.8
作者：
DACEY, DM;LEE, BB
通讯作者：
LEE, BB
影响因子：
2.5
作者：
DeVries, SH;Baylor, DA
通讯作者：
Baylor, DA
影响因子：
64.8
作者：
CALKINS, DJ;SCHEIN, SJ;STERLING, P
通讯作者：
STERLING, P