CD169 Expression on Lymph Node Macrophages Predicts in Patients With Gastric Cancer.
CD169 Expression on Lymph Node Macrophages Predicts in Patients With Gastric Cancer.
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CD169对淋巴结巨噬细胞的表达预测胃癌患者。
DOI：
10.3389/fonc.2021.636751
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发表时间：
2021
影响因子：
4.7
通讯作者：
Nakayama T
中科院分区：
文献类型：
--
作者：
Kumamoto K;Tasaki T;Ohnishi K;Shibata M;Shimajiri S;Harada M;Komohara Y;Nakayama T
抗癌免疫反应的诱导可能与抗癌疗法的疗效相关。近期研究表明，区域淋巴结中的窦巨噬细胞参与癌症微环境中的抗癌免疫反应。在本研究中，我们调查了癌组织中淋巴细胞浸润与区域淋巴结中巨噬细胞活化之间的相关性。我们回顾性地确定了2008年至2012年接受手术的294例胃癌患者。通过免疫组织化学方法，我们评估了CD68阳性巨噬细胞上CD169的表达以及肿瘤微环境中CD8阳性淋巴细胞的密度。我们对CD169和CD8表达之间的相关性进行了统计学检验，并对包括CD169和CD8表达在内的潜在预后因素进行了针对胃癌总体患者和进展期胃癌患者癌症特异性生存期（CSS）的Cox回归分析。淋巴结窦巨噬细胞（LySMs）中CD169的过表达与原发癌组织中CD8阳性淋巴细胞的密度呈正相关（R = 0.367，p < 0.001）。原发部位CD8阳性T淋巴细胞的高密度以及LySMs中CD169的高表达与胃癌总体患者和进展期胃癌患者更好的CSS独立相关（所有p < 0.05）。LySMs中CD169的表达是胃癌患者良好临床病程的一个预测指标，可能有助于评估抗癌免疫反应。
The induction of an anti-cancer immune responses is potentially associated with the efficacy of anti-cancer therapy. Recent studies have indicated that sinus macrophages in regional lymph nodes are involved in anti-cancer immune responses in the cancer microenvironment. In the present study, we investigated the correlation between lymphocyte infiltration in cancer tissues and macrophage activation in regional lymph nodes. We retrospectively identified 294 patients with gastric cancer who underwent surgery from 2008 to 2012. Using immunohistochemistry, we evaluated CD169-expression on CD68-positive macrophages, and the density of CD8-postive lymphocytes in tumor microenvironment. We statistically examined the correlation between CD169 and CD8 expression, and performed Cox regression analysis of potential prognostic factors, including CD169 and CD8 expression, for cancer-specific survival (CSS) in patients with total and advanced gastric cancer. CD169 overexpression in lymph node sinus macrophages (LySMs) was positively correlated to the density of CD8-positive lymphocytes in primary cancer tissues (R = 0.367, p < 0.001). A high density of CD8-positive T lymphocytes in the primary site and a high level of CD169 expression in LySMs were independently associated with greater CSS in patients with total and advanced gastric cancer (p < 0.05 for all). The expression on CD169 in LySMs is a predictor of a favorable clinical course in patients with gastric cancer, and might be useful for evaluating anti-cancer immune responses.
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