Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.
Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.
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DOI：
10.3390/nu8090545
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发表时间：
2016-09-06
期刊：
影响因子：
5.9
通讯作者：
Tanaka H
中科院分区：
文献类型：
--
作者：
Nanri H;Nishida Y;Nakamura K;Tanaka K;Naito M;Yin G;Hamajima N;Takashima N;Suzuki S;Nindita Y;Kohno M;Uemura H;Koyama T;Hosono S;Mikami H;Kubo M;Tanaka H
研究了饮食模式与2种β-肾上腺素能受体（ADRβ）基因多态性（ADRβ2 Gln 27 Glu和ADRβ3 Trp 64 Arg）对血清甘油三酯水平的影响。这项横断面研究包括1720名男性和女性（年龄35-69岁），他们参加了日本多机构协作队列（J-MICC）研究。使用多重聚合酶链反应为基础的入侵检测进行基因分型。我们使用46个项目，从一个有效的短的食物频率问卷，并检查主要的饮食模式的因素分析。我们确定了四种饮食模式：健康，西方，海鲜和面包模式。任何饮食模式与血清甘油三酯水平之间均无显著相关性。在单独的基于基因型的分析后，ADRβ3 Trp 64 Arg基因型和面包模式之间的显著相互作用（相互作用p = 0.01）与血清甘油三酯水平相关;具体而言，在调整混杂因素后，面包模式的Arg等位基因携带者血清甘油三酯较低（趋势p = 0.01）。然而，面包型Trp/Trp纯合子受试者与血清甘油三酯无关（趋势p = 0.55）。其他饮食模式与ADRβ基因多态性之间的交互作用对血清甘油三酯水平无显著影响。我们的研究结果表明，ADRβ3多态性改变了面包模式对甘油三酯水平的影响。
Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
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影响因子：
4.5
作者：
Akter S;Nanri A;Pham NM;Kurotani K;Mizoue T
通讯作者：
Mizoue T
影响因子：
4.7
作者：
Hara M;Higaki Y;Taguchi N;Shinchi K;Morita E;Naito M;Hamajima N;Takashima N;Suzuki S;Nakamura A;Ohnaka K;Uemura H;Nishida H;Hosono S;Mikami H;Kubo M;Tanaka H;Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
通讯作者：
Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
影响因子：
7.1
作者：
Lopez-Garcia, E;Schulze, MB;Hu, FB
通讯作者：
Hu, FB
影响因子：
4.7
作者：
Hara M;Nakamura K;Nanri H;Nishida Y;Hishida A;Kawai S;Hamajima N;Kita Y;Suzuki S;Mantjoro EM;Ohnaka K;Uemura H;Matsui D;Oze I;Mikami H;Kubo M;Tanaka H;Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
通讯作者：
Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
影响因子：
4.9
作者：
Kim, OY;Cho, EY;Lee, JH
通讯作者：
Lee, JH