Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.
Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.
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DOI：
10.2188/jea.je20140002
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发表时间：
2014
影响因子：
4.7
通讯作者：
Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
中科院分区：
文献类型：
--
作者：
Hara M;Nakamura K;Nanri H;Nishida Y;Hishida A;Kawai S;Hamajima N;Kita Y;Suzuki S;Mantjoro EM;Ohnaka K;Uemura H;Matsui D;Oze I;Mikami H;Kubo M;Tanaka H;Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
有证据表明，Ser326Cys（人 8-氧鸟嘌呤糖基化酶 1 (hOGG1) 的遗传多态性）与胰岛素抵抗和 2 型糖尿病相关；然而，其根本机制尚不清楚。最近，一项动物研究表明 hOGG1 基因型与肥胖之间存在显着关联，尽管人类中这种关联的证据有限。本研究的目的是检查 hOGG1 基因型与体重指数 (BMI) 和空腹血糖 (FBG) 水平之间的关联。使用日本多机构协作队列研究的基线调查数据进行横断面分析，该研究包括 1793 名年龄在 40-69 岁之间的参与者。使用基于多重聚合酶链反应的入侵检测检测 hOGG1 多态性。使用多元线性回归、协方差分析和逻辑回归来控制混杂变量。即使在调整了性别、年龄、能量摄入、酒精、吸烟、体力活动和糖尿病家族史之后，Cys 等位基因与 BMI、FBG 水平和总胆固醇 (TC) 水平显着相关。进一步调整 FBG 和 TC 后，仍然观察到与 BMI 的关联，但在研究区域（奄美或大陆）则不然。 Cys/Cys 基因型在 BMI 较高（>27.5 kg/m2）的参与者中显着更为普遍。然而，在对研究区域进行调整后，基因型的影响减弱，显着性消失。目前的结果表明，日本境内的研究区域混淆了 hOGG1 基因型与肥胖之间的关联。
Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels. Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40–69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables. The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m2). However, the impact of genotype decreased and significance disappeared after adjusting for the study area. The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.
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DOI：
10.20452/pamw.626
发表时间：
2009-03-01
影响因子：
--
作者：
Kasznicki, Jacek;Krupa, Renata;Drzewoski, Jozef
通讯作者：
Drzewoski, Jozef
影响因子：
4.7
作者：
Wakai K;Hamajima N;Okada R;Naito M;Morita E;Hishida A;Kawai S;Nishio K;Yin G;Asai Y;Matsuo K;Hosono S;Ito H;Watanabe M;Kawase T;Suzuki T;Tajima K;Tanaka K;Higaki Y;Hara M;Imaizumi T;Taguchi N;Nakamura K;Nanri H;Sakamoto T;Horita M;Shinchi K;Kita Y;Turin TC;Rumana N;Matsui K;Miura K;Ueshima H;Takashima N;Nakamura Y;Suzuki S;Ando R;Hosono A;Imaeda N;Shibata K;Goto C;Hattori N;Fukatsu M;Yamada T;Tokudome S;Takezaki T;Niimura H;Hirasada K;Nakamura A;Tatebo M;Ogawa S;Tsunematsu N;Chiba S;Mikami H;Kono S;Ohnaka K;Takayanagi R;Watanabe Y;Ozaki E;Shigeta M;Kuriyama N;Yoshikawa A;Matsui D;Watanabe I;Inoue K;Ozasa K;Mitani S;Arisawa K;Uemura H;Hiyoshi M;Takami H;Yamaguchi M;Nakamoto M;Takeda H;Kubo M;Tanaka H;J-MICC Study Group
通讯作者：
J-MICC Study Group
影响因子：
3.7
作者：
Duan WX;Hua RX;Yi W;Shen LJ;Jin ZX;Zhao YH;Yi DH;Chen WS;Yu SQ
通讯作者：
Yu SQ
影响因子：
4.7
作者：
Hara M;Higaki Y;Taguchi N;Shinchi K;Morita E;Naito M;Hamajima N;Takashima N;Suzuki S;Nakamura A;Ohnaka K;Uemura H;Nishida H;Hosono S;Mikami H;Kubo M;Tanaka H;Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
通讯作者：
Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
HOGG1 Ser326Cys多态性对癌症风险的影响：荟萃分析的证据。
影响因子：
3.7
作者：
Wei B;Zhou Y;Xu Z;Xi B;Cheng H;Ruan J;Zhu M;Hu Q;Wang Q;Wang Z;Yan Z;Jin K;Zhou D;Xuan F;Huang X;Shao J;Lu P
通讯作者：
Lu P