Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis.
Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis.
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DOI：
10.1186/s12951-020-00755-7
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发表时间：
2021-01-04
影响因子：
10.2
通讯作者：
Alizadeh Z
中科院分区：
文献类型：
--
作者：
Nosrati H;Aramideh Khouy R;Nosrati A;Khodaei M;Banitalebi-Dehkordi M;Ashrafi-Dehkordi K;Sanami S;Alizadeh Z
皮肤是人体抵御外部病原体的第一道屏障，维持身体的内稳态。对皮肤的任何严重损害都可能对人体健康和生活质量产生影响。组织工程旨在提高损伤组织的再生质量。皮肤组织再生最有效的治疗方法之一是在愈合期间促进血管生成。在过去的十年中，纳米生物材料在组织工程中的潜在应用有了令人印象深刻的增长。为了提高血管生成纳米材料愈合过程的速度和质量，已经开发了各种方法。在这篇综述中，我们主要关注血管生成的分子机制和关键因素，纳米生物材料在血管生成中的作用，以及基于支架的组织工程方法在改善血管生成的基础上加速伤口愈合。
Skin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.
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影响因子：
0.9
作者：
Bauer, Stephen M;Bauer, Richard J;Velazquez, Omaida C
通讯作者：
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影响因子：
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