Botulinum Toxin Therapy for Spasmodic Dysphonia in Japan: The History and an Update.
Botulinum Toxin Therapy for Spasmodic Dysphonia in Japan: The History and an Update.
复制标题
日本痉挛性发声障碍的肉毒毒素治疗：历史和更新。
作者：
痉挛性发声障碍是一种罕见的神经系统疾病，通过触发喉内肌的不自主和间歇性收缩来损害发声功能。SD分为三种类型：内收肌SD（AdSD）、外展肌SD（AbSD）和混合型SD。其中，AdSD占疾病的90-95%;年轻女性主要受影响。肉毒杆菌毒素注射到喉肌肉是安全的，微创的，非常有效。在这里，我们回顾了在日本进行的SD临床研究的历史。在日本，小林等人于1989年首次使用肉毒杆菌毒素注射疗法治疗SD。该小组开发了一种客观的莫拉（音节）方法来评估SD的严重程度。最近，我们进行了一项安慰剂对照，随机，双盲临床试验的肉毒杆菌毒素治疗AdSD和一个开放标签试验AbSD，以获得日本医疗保险系统的批准，这种治疗。莫拉法显示声音有显著改善，证据质量高。此外，一项使用钛桥的2型甲状腺成形术的临床试验证实了这种疗法的有效性和安全性。这些研究拓宽了SD的治疗选择，并使患者显著受益。
Spasmodic dysphonia (SD) is a rare neurological disorder that impairs phonatory function by triggering involuntary and intermittent contractions of the intrinsic laryngeal muscles. SD is classified into three types: adductor SD (AdSD), abductor SD (AbSD), and mixed SD. Of these, AdSD accounts for 90–95% of disease; younger females are predominantly affected. Botulinum toxin injection into the laryngeal muscles is safe, minimally invasive, and very effective. Here, we review the history of clinical research for SD conducted in Japan. The first use of botulinum toxin injection therapy to treat SD in Japan was by Kobayashi et al. in 1989. The group developed an objective mora (syllable) method to evaluate SD severity. Recently, we conducted a placebo-controlled, randomized, double-blinded clinical trial of botulinum toxin therapy for AdSD and an open-label trial for AbSD to obtain the approval of such therapy by the Japanese medical insurance system. The mora method revealed significant voice improvement and the evidence was of high quality. Additionally, a clinical trial of type 2 thyroplasty using titanium bridges confirmed the efficacy and safety of such therapy. These studies broadened the SD treatment options and have significantly benefited patients.
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影响因子：
4.2
作者：
Hyodo M;Asano K;Nagao A;Hirose K;Nakahira M;Yanagida S;Nishizawa N
通讯作者：
Nishizawa N
影响因子：
8.6
作者：
Asgeirsson, H;Jakobsson, F;Sveinbjornsdottir, S
通讯作者：
Sveinbjornsdottir, S
DOI：
10.1044/1092-4388(2002/037
发表时间：
2002-06-01
影响因子：
2.6
作者：
Boutsen, F;Cannito, MR;Bender, B
通讯作者：
Bender, B
影响因子：
2.2
作者：
Bradley, Joseph P.;Barrow, Emily M.;Johns, Michael M., III
通讯作者：
Johns, Michael M., III
影响因子：
1.4
作者：
Berke, GS;Blackwell, KE;Sercarz, JA
通讯作者：
Sercarz, JA