The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
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DOI：
10.1038/s41467-021-27288-3
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发表时间：
2021-11-25
影响因子：
16.6
通讯作者：
Moscou MJ
中科院分区：
文献类型：
--
作者：
Bettgenhaeuser J;Hernández-Pinzón I;Dawson AM;Gardiner M;Green P;Taylor J;Smoker M;Ferguson JN;Emmrich P;Hubbard A;Bayles R;Waugh R;Steffenson BJ;Wulff BBH;Dreiseitl A;Ward ER;Moscou MJ
植物病原体造成的作物损失是粮食稳定生产的主要威胁。条锈病（Pucciniastriiformis）是禾谷类作物的真菌病原体，其导致显著的、持续的产量损失。条锈病表现出寄主物种特异性，具有适应感染小麦和大麦的谱系。虽然小麦条锈病和大麦条锈病通常限于其相应的宿主，但这种宿主特异性的基因仍然未知。在这里，我们表明三个抗性基因Rps6、Rps7和Rps8有助于大麦对小麦条锈的免疫力。Rps7在Mla位点与大麦白粉病抗性共分离。利用不同Mla等位基因的转基因互补，我们证实了Mla对小麦条锈病的等位基因特异性识别。我们的研究结果表明，主要的抗性基因有助于小麦条锈病对大麦的寄主物种特异性和一个共同的遗传结构的基础上适应病原大麦白粉病和非适应病原小麦条锈病的抗性。小麦和大麦之间的条锈病寄主特异性的基因仍然未知。在这里，作者报告说，Rps6，Rps7和Rps8决定大麦中病原体生命周期不同阶段的宿主物种特异性，大麦白粉病免疫受体Mla 8和Rps7是相同的基因。
Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust. The genes underlying stripe rust host specificity between wheat and barley remain unknown. Here, the authors report that Rps6, Rps7 and Rps8 determine host species specificity in barley at different stages of the pathogen lifecycle and the barley powdery mildew immune receptor Mla8 and Rps7 are the same gene.
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影响因子：
5.6
作者：
Dawson AM;Bettgenhaeuser J;Gardiner M;Green P;Hernández-Pinzón I;Hubbard A;Moscou MJ
通讯作者：
Moscou MJ
影响因子：
1.5
作者：
Briggs, FN;Stanford, EH
通讯作者：
Stanford, EH
DOI：
10.1007/s00122-015-2659-x
发表时间：
2016-04
期刊：
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
影响因子：
--
作者：
Dawson AM;Ferguson JN;Gardiner M;Green P;Hubbard A;Moscou MJ
通讯作者：
Moscou MJ
影响因子：
56.9
作者：
de Jonge, Ronnie;van Esse, H. Peter;Thomma, Bart P. H. J.
通讯作者：
Thomma, Bart P. H. J.
影响因子：
4.9
作者：
Debieu, Marilyne;Huard-Chauveau, Carine;Roby, Dominique
通讯作者：
Roby, Dominique