Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies.
Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies.
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DOI：
10.1007/s10654-012-9674-x
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发表时间：
2012-05
影响因子：
13.6
通讯作者：
Rivadeneira, Fernando
中科院分区：
文献类型：
--
作者：
Ma, Lili;Oei, Ling;Jiang, Lindi;Estrada, Karol;Chen, Huiyong;Wang, Zhen;Yu, Qiang;Zillikens, Maria Carola;Gao, Xin;Rivadeneira, Fernando
2 型糖尿病 (T2DM) 影响骨代谢，但 T2DM 与骨矿物质密度 (BMD) 的关系在各个研究中仍然不一致。本研究的目的是对文献进行荟萃分析和荟萃回归，以估计糖尿病和非糖尿病人群之间 BMD (g/cm2) 的差异，并调查潜在的潜在机制。在 PubMed 和 Ovid 中进行文献检索，从 2010 年 5 月之前的文章中提取数据。符合条件的研究是那些使用横断面、队列或病例对照设计（包括健康对照和 T2DM 受试者）评估通过双能 X 射线骨密度测定法测量的 T2DM 和 BMD 之间关联的研究。该分析是针对 15 项观察性研究（3,437 名糖尿病患者和 19,139 名对照者）进行的。荟萃分析显示，糖尿病患者的 BMD 显着较高，股骨颈的汇总平均差异为 0.04 (95% CI: 0.02, 0.05)，髋部的汇总平均差异为 0.06 (95% CI: 0.04, 0.08)，脊柱的汇总平均差异为 0.06 (95% CI: 0.04, 0.07)。糖尿病患者和非糖尿病患者的前臂 BMD 差异没有显着差异。性别分层分析显示，两种性别的结果相似。研究发现，显着的异质性源于研究设计的差异以及可能的糖尿病定义。此外，通过应用荟萃回归，我们可以确定糖尿病患者的年龄较小、男性、较高的体重指数和较高的 HbA1C 与较高的 BMD 水平呈正相关。我们得出的结论是，两性 T2DM 患者的 BMD 水平均较高，但影响 T2DM 患者 BMD 的因素有多种。
Type 2 diabetes mellitus (T2DM) influences bone metabolism, but the relation of T2DM with bone mineral density (BMD) remains inconsistent across studies. The objective of this study was to perform a meta-analysis and meta-regression of the literature to estimate the difference in BMD (g/cm2) between diabetic and non-diabetic populations, and to investigate potential underlying mechanisms. A literature search was performed in PubMed and Ovid extracting data from articles prior to May 2010. Eligible studies were those where the association between T2DM and BMD measured by dual energy X-ray absorptiometry was evaluated using a cross-sectional, cohort or case–control design, including both healthy controls and subjects with T2DM. The analysis was done on 15 observational studies (3,437 diabetics and 19,139 controls). Meta-analysis showed that BMD in diabetics was significantly higher, with pooled mean differences of 0.04 (95% CI: 0.02, 0.05) at the femoral neck, 0.06 (95% CI: 0.04, 0.08) at the hip and 0.06 (95% CI: 0.04, 0.07) at the spine. The differences for forearm BMD were not significantly different between diabetics and non-diabetics. Sex-stratified analyses showed similar results in both genders. Substantial heterogeneity was found to originate from differences in study design and possibly diabetes definition. Also, by applying meta-regression we could establish that younger age, male gender, higher body mass index and higher HbA1C were positively associated with higher BMD levels in diabetic individuals. We conclude that individuals with T2DM from both genders have higher BMD levels, but that multiple factors influence BMD in individuals with T2DM.
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影响因子：
3
作者：
Anaforoglu, Inan;Nar-Demirer, Ash;Ertorer, Melek Eda
通讯作者：
Ertorer, Melek Eda
影响因子：
3.8
作者：
Bridges, MJ;Moochhala, SH;Kelly, CA
通讯作者：
Kelly, CA
影响因子：
4
作者：
Christensen, JO;Svendsen, OL
通讯作者：
Svendsen, OL
影响因子：
6.2
作者：
Giangregorio, Lora M.;Leslie, William D.;Kanis, John A.
通讯作者：
Kanis, John A.
影响因子：
3.3
作者：
Gomez-Ambrosi, Javier;Fruehbeck, Gema
通讯作者：
Fruehbeck, Gema