Negative energy balance hinders prosocial helping behavior.
Negative energy balance hinders prosocial helping behavior.
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DOI：
10.1073/pnas.2218142120
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发表时间：
2023-04-11
影响因子：
11.1
通讯作者：
Claret, Marc
中科院分区：
文献类型：
--
作者：
Pozo, Macarena;Mila-Guasch, Maria;Haddad-Tovolli, Roberta;Boudjadja, Mehdi Boutagouga;Chivite, Inigo;Toledo, Miriam;Gomez-Valades, Alicia G.;Eyre, Elena;Ramirez, Sara;Obri, Arnaud;Bartal, Inbal Ben-Ami;DAgostino, Giuseppe;Costa-Font, Joan;Claret, Marc
在本研究中，我们探讨了动物体内代谢状态对亲社会帮助行为的影响。我们发现，饥饿或营养有限的情况下，减少帮助行为对同种在困境中。这些结果代表了亲社会科学领域的重大进展，因为它们为复杂的动物行为提供了见解。此外，我们的工作还证明，特定的下丘脑神经元处于代谢控制和帮助行为的界面，从而整合了稳态和社会线索。动物的内部状态，包括自我平衡的要求，调节其行为。负能量平衡刺激饥饿，从而促进一系列旨在获得食物的行动。虽然这些生存行为已经很好地建立起来，但能量状态对亲社会行为的影响仍然没有被探索。我们开发了一个范例来评估帮助行为，其中一个自由的小鼠面临着一个同种被困在一个限制器。我们测量了自由小鼠在不同代谢条件下释放受限小鼠的意愿。大约42%的自由进食的小鼠表现出帮助行为，如通过释放捕获的笼蛋白的乳酸减少所证明的。这种行为是独立的，随后的社会接触奖励，并与皮质酮的变化表明情绪传染。这一决策过程伴随着血糖波动的减少和辅助小鼠前脑中三磷酸腺苷（ATP）：二磷酸腺苷（ADP）比率的升高，这表明这是一个高能量需求的过程。有趣的是，慢性（食物限制和2型糖尿病）和急性（促进饥饿的AgRP神经元的化学发生激活）的情况下，模仿生物体的负能量平衡和增强食欲衰减帮助行为对一个痛苦的同种。为了研究人类的类似效应，我们使用理解社会数据集估计了糖化血红蛋白（长期血糖控制的替代品）对亲社会行为（即慈善捐赠）的影响。我们的研究结果表明，有机体的能量状态显着影响帮助行为和下丘脑AgRP神经元的代谢和亲社会行为的接口。
In the current study, we investigate the influence of the metabolic internal state of an animal on prosocial helping behavior. We found that situations that entail hunger or limited nutrient availability correlated with a reduced helping behavior toward a conspecific in distress. These results represent a significant advance in the field of prosocial science as they provide insights into complex animal behaviors. Furthermore, our work also evidence that specific hypothalamic neurons are at the interface of metabolic control and helping behavior, thus integrating homeostatic and social cues. The internal state of an animal, including homeostatic requirements, modulates its behavior. Negative energy balance stimulates hunger, thus promoting a range of actions aimed at obtaining food. While these survival actions are well established, the influence of the energy status on prosocial behavior remains unexplored. We developed a paradigm to assess helping behavior in which a free mouse was faced with a conspecific trapped in a restrainer. We measured the willingness of the free mouse to liberate the confined mouse under diverse metabolic conditions. Around 42% of ad libitum–fed mice exhibited a helping behavior, as evidenced by the reduction in the latencies to release the trapped cagemate. This behavior was independent of subsequent social contact reward and was associated with changes in corticosterone indicative of emotional contagion. This decision-making process was coupled with reduced blood glucose excursions and higher Adenosine triphosphate (ATP):Adenosine diphosphate (ADP) ratios in the forebrain of helper mice, suggesting that it was a highly energy-demanding process. Interestingly, chronic (food restriction and type 2 diabetes) and acute (chemogenetic activation of hunger-promoting AgRP neurons) situations mimicking organismal negative energy balance and enhanced appetite attenuated helping behavior toward a distressed conspecific. To investigate similar effects in humans, we estimated the influence of glycated hemoglobin (a surrogate of long-term glycemic control) on prosocial behavior (namely charity donation) using the Understanding Society dataset. Our results evidenced that organismal energy status markedly influences helping behavior and that hypothalamic AgRP neurons are at the interface of metabolism and prosocial behavior.
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影响因子：
16.2
作者：
Burnett CJ;Li C;Webber E;Tsaousidou E;Xue SY;Brüning JC;Krashes MJ
通讯作者：
Krashes MJ
影响因子：
64.5
作者：
Dietrich MO;Zimmer MR;Bober J;Horvath TL
通讯作者：
Horvath TL
影响因子：
11
作者：
Besnard A;Leroy F
通讯作者：
Leroy F
影响因子：
20.3
作者：
Jais A;Brüning JC
通讯作者：
Brüning JC
影响因子：
56.9
作者：
Ahmadlou, Mehran;Houba, Janou H. W.;Heimel, J. Alexander
通讯作者：
Heimel, J. Alexander