Top-down regulation of motivated behaviors via lateral septum sub-circuits.
Top-down regulation of motivated behaviors via lateral septum sub-circuits.
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DOI：
10.1038/s41380-022-01599-3
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发表时间：
2022-08
影响因子：
11
通讯作者：
Leroy F
中科院分区：
文献类型：
--
作者：
Besnard A;Leroy F
认知如何调节先天行为？虽然大脑皮层的认知功能已被广泛研究，但我们对认知如何调节先天动机行为以满足生理、安全和社会需求知之甚少。选择适当的动机行为取决于外部刺激和过去的经验，这有助于衡量优先级。外侧隔（LS）有大量来自新皮质和异皮质区域的输入，是整合感知和体验信号以调节控制动机行为的下丘脑和中脑核活动的理想位置。此外，LS接收大量皮层下调节输入，这些输入代表动物的内部状态，也参与这种调节。从这个角度来看，我们认为LS子回路通过整合来自新皮质、异皮质和神经调节输入的神经活动来调节不同的动机行为。此外，我们提出LS子回路之间的横向抑制可能允许协调竞争动机行为的功能单元的出现。
How does cognition regulate innate behaviors? While the cognitive functions of the cortex have been extensively studied, we know much less about how cognition can regulate innate motivated behaviors to fulfill physiological, safety and social needs. Selection of appropriate motivated behaviors depends on external stimuli and past experiences that helps to scale priorities. With its abundant inputs from neocortical and allocortical regions, the lateral septum (LS) is ideally positioned to integrate perception and experience signals in order to regulate the activity of hypothalamic and midbrain nuclei that control motivated behaviors. In addition, LS receives numerous subcortical modulatory inputs, which represent the animal internal states and also participate in this regulation. In this perspective, we argue that LS sub-circuits regulate distinct motivated behaviors by integrating neural activity from neocortical, allocortical and neuromodulatory inputs. In addition, we propose that lateral inhibition between LS sub-circuits may allow the emergence of functional units that orchestrates competing motivated behaviors.
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