Estrogens facilitate memory processing through membrane mediated mechanisms and alterations in spine density.
Estrogens facilitate memory processing through membrane mediated mechanisms and alterations in spine density.
复制标题
DOI：
10.1016/j.yfrne.2012.07.004
复制
发表时间：
2012-10
影响因子：
7.4
通讯作者：
Frankfurt, Maya
中科院分区：
文献类型：
--
作者：
Luine, Victoria N.;Frankfurt, Maya
关键词：
雌激素在整个女性生命周期中对记忆施加持续的、基因介导的影响，但这里我们综述了新的研究，这些研究记录了雌激素对记忆的快速影响，这些效应是通过膜介导的机制发挥的。对老鼠的识别记忆任务的使用表明，雌激素在一小时内增强了记忆巩固。17α-雌二醇的作用强于17β-雌二醇，雌激素与记忆的量效关系呈倒U形。使用特定的雌激素受体(ER)激动剂提示由ERβ样膜受体介导。记忆力的增强与30分钟内脊柱密度的增加以及内侧前额叶皮质和海马区去甲肾上腺素能活动的改变有关。行政管理部门。环境化学物质双酚-A可能通过对脊椎的作用而迅速对抗两性记忆力的增强。因此，雌二醇和相关化合物通过非基因组机制在认知方面产生快速变化，这一发现可能为更好地理解和治疗记忆障碍提供基础。
Estrogens exert sustained, genomically mediated effects on memory throughout the female life cycle, but here we review new studies documenting rapid effects of estradiol on memory, which are exerted through membrane-mediated mechanisms. Use of recognition memory tasks in rats, shows that estrogens enhance memory consolidation within one hour. 17α-estradiol is more potent than 17β-estradiol, and the dose response relationship between estrogens and memory is an inverted U shape. Use of specific estrogen receptor (ER) agonists suggests mediation by an ERβ-like membrane receptor. Enhanced memory is associated with increased spine density and altered noradrenergic activity in the medial prefrontal cortex and hippocampus within 30 min. of administration. The environmental chemical, bisphenol-A, rapidly antagonizes enhancements in memory in both sexes possibly through actions on spines. Thus, estradiol and related compounds exert rapid alterations in cognition through non-genomic mechanisms, a finding which may provide a basis for better understanding and treating memory impairments.
登录
查看更多内容
影响因子：
4.8
作者：
Calizo, LH;Flanagan-Cato, LM
通讯作者：
Flanagan-Cato, LM
影响因子：
2.9
作者：
Beck, KD;Luine, VN
通讯作者：
Luine, VN
影响因子：
3.5
作者：
Daniel, JM;Fader, AJ;Dohanich, GP
通讯作者：
Dohanich, GP
DOI：
10.2201/nonlin.003.01.002
发表时间：
2005-01-01
期刊：
Nonlinearity in Biology Toxicology and Medicine
影响因子：
--
作者：
Baldi, Elisabetta;Bucherelli, Corrado
通讯作者：
Bucherelli, Corrado
影响因子：
4.8
作者：
EVERETT, JW
通讯作者：
EVERETT, JW