Targeted memory reactivation during sleep can induce forgetting of overlapping memories.
Targeted memory reactivation during sleep can induce forgetting of overlapping memories.
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DOI：
10.1101/lm.053594.122
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发表时间：
2022-11
影响因子：
2
通讯作者：
Horner, Aidan J.
中科院分区：
文献类型：
--
作者：
Joensen, Barour H.;Harrington, Marcus O.;Berens, Sam C.;Cairney, Scott A.;Gaskell, M. Gareth;Horner, Aidan J.
睡眠期间的记忆重新激活可以将新记忆塑造成长期形式。记忆的重新激活可以通过睡眠期间传递听觉线索来诱导。尽管这种有针对性的记忆重新激活（TMR）方法可以强化新获得的记忆，但研究往往集中在单一的联想记忆上。目前尚不清楚 TMR 如何影响重叠联想记忆的保留。这是至关重要的，因为在清醒期间重复检索重叠的关联可能会导致遗忘，这种现象称为检索诱发遗忘（RIF）。我们询问，当 TMR 用于提示睡眠期间重叠的成对关联重新激活时，是否会发生类似的遗忘模式。参与者学习重叠的配对——单独学习，与其他不相关的配对交错学习。在睡眠期间，我们使用 TMR 提示了重叠对的子集。虽然 TMR 提高了第一个编码对的记忆力，但第二个编码对的记忆力却下降了。这种保留模式仅出现在睡眠前未测试的配对中。结果表明，TMR 会导致遗忘，其效果类似于清醒时的 RIF。然而，这种效应并没有延伸到通过睡前检索而得到强化的记忆。因此，我们提供了睡眠期间重新激活诱发的遗忘效应的证据。
Memory reactivation during sleep can shape new memories into a long-term form. Reactivation of memories can be induced via the delivery of auditory cues during sleep. Although this targeted memory reactivation (TMR) approach can strengthen newly acquired memories, research has tended to focus on single associative memories. It is less clear how TMR affects retention for overlapping associative memories. This is critical, given that repeated retrieval of overlapping associations during wake can lead to forgetting, a phenomenon known as retrieval-induced forgetting (RIF). We asked whether a similar pattern of forgetting occurs when TMR is used to cue reactivation of overlapping pairwise associations during sleep. Participants learned overlapping pairs—learned separately, interleaved with other unrelated pairs. During sleep, we cued a subset of overlapping pairs using TMR. While TMR increased retention for the first encoded pairs, memory decreased for the second encoded pairs. This pattern of retention was only present for pairs not tested prior to sleep. The results suggest that TMR can lead to forgetting, an effect similar to RIF during wake. However, this effect did not extend to memories that had been strengthened via retrieval prior to sleep. We therefore provide evidence for a reactivation-induced forgetting effect during sleep.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
DOI：
10.1016/j.cub.2018.01.087
发表时间：
2018-03-19
期刊：
Current biology : CB
影响因子：
--
作者：
Cairney SA;Guttesen AÁV;El Marj N;Staresina BP
通讯作者：
Staresina BP
影响因子：
3.7
作者：
通讯作者：
--
DOI：
10.1037/0278-7393.20.5.1063
发表时间：
1994-09-01
影响因子：
2.6
作者：
ANDERSON, MC;BJORK, RA;BJORK, EL
通讯作者：
BJORK, EL
影响因子：
3.5
作者：
Anderson, MC;Bjork, EL;Bjork, RA
通讯作者：
Bjork, RA