The role of fundus autofluorescence imaging in the study of the course of posterior uveitis disorders.
The role of fundus autofluorescence imaging in the study of the course of posterior uveitis disorders.
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DOI：
10.1155/2015/247469
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发表时间：
2015
影响因子：
--
通讯作者：
Markomichelakis NN
中科院分区：
文献类型：
--
作者：
Malamos P;Masaoutis P;Georgalas I;Maselos S;Andrianopoulos K;Koutsandrea C;Markomichelakis NN
背景。评估患有各种后葡萄膜炎疾病的患者眼底自发荧光（FAF）与吲哚菁绿血管造影（ICGA）的相关性。方法。介入病例系列包括诊断为特定类型视网膜脉络膜炎的 15 名患者的 23 只眼睛，例如急性后多灶性鳞状色素上皮病 (APMPPE)、匐行状脉络膜炎、多灶性脉络膜炎 (MFC)、原田病和梅毒性视网膜脉络膜炎。此外，还包括一些未明确的视网膜脉络膜炎病例。在基线和治疗后随访期间进行 FAF 和 ICGA 并进行关联。结果。在 ICGA 中，发现早期低荧光是急性脉络膜炎症的标志，在晚期阶段消退，并在视网膜色素上皮 (RPE) 损伤区域保留在晚期阶段。边界不清的高自身荧光区域与急性脉络膜病变相关。低自身荧光描绘表明 RPE 愈合过程的开始，与 ICGA 的后期阶段良好相关并描绘了 RPE 损伤。 ICGA 中早期的自发荧光强和晚期的低荧光表明存在原发性 RPE 受累。结论。 FAF 有助于解释 RPE 疾病，并且可能是跟踪进行性炎症性疾病的有用工具。 FAF 和 ICGA 的比较评估可以表征炎症事件的顺序和受影响组织的水平。
Background. To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders. Methods. Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis. Also, some cases with undefined retinochoroiditis were included. FAF and ICGA were performed and correlated at baseline and during follow-up after treatment. Results. In ICGA, early hypofluorescence was found to be the hallmark of acute choroidal inflammation, resolving in later stages and remaining in the late phase in areas with retinal pigment epithelium (RPE) damage. Poorly defined hyperautofluorescent areas correlated with acute choroidal lesions. Hypoautofluorescent delineation suggested the initiation of RPE healing processes, correlating well with the late phase of ICGA and delineating the RPE damage. Early hyperautofluorescence with late hypofluorescence in ICGA indicated the presence of primary RPE involvement. Conclusion. FAF contributes to the interpretation of RPE disease and may be a useful tool for the follow-up of progressive inflammatory disorders. Comparative evaluation of FAF and ICGA allows a characterization of the sequence of inflammatory events and the level of tissue affected.
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影响因子：
1.6
作者：
Rao, Narsing A.
通讯作者：
Rao, Narsing A.
影响因子：
13.7
作者：
Spaide, Richard F.;Noble, Kenneth;Freund, K. Bailey
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Freund, K. Bailey
影响因子：
13.7
作者：
Spaide, RF
通讯作者：
Spaide, RF
影响因子：
13.7
作者：
Shiraga, F;Ojima, Y;Matsuo, N
通讯作者：
Matsuo, N
影响因子：
4.2
作者：
Haen, Sebastian P.;Spaide, Richard F.
通讯作者：
Spaide, Richard F.