Imagining fictitious and future experiences: evidence from developmental amnesia.
Imagining fictitious and future experiences: evidence from developmental amnesia.
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DOI：
10.1016/j.neuropsychologia.2010.06.037
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发表时间：
2010-09
期刊：
影响因子：
2.6
通讯作者：
Hassabis D
中科院分区：
文献类型：
--
作者：
Maguire EA;Vargha-Khadem F;Hassabis D
▶ Jon 是一位患有发育性遗忘症和双侧海马损伤的患者。 ▶ 尽管如此，他仍然能够丰富地想象虚构的和未来的场景。 ▶ 这与大多数成人获得性遗忘症患者形成鲜明对比。 ▶ 残余的海马功能可能支持保留的模拟能力。据报道，成年后双侧海马体受损、对过去事件失忆的患者在想象虚构和未来经历方面也受到损害。然而，其中一位名为 P01 的患者被发现在执行这些任务时没有受到任何影响，尽管他有严重的健忘症，并且两个海马体的体积都减少了 50%。 P01 可能是一个非典型病例，为了调查这一点，我们确定了另一位具有类似神经心理学特征的患者。乔恩 (Jon) 是一位患有发育性遗忘症且海马体容量减少 50% 的典型患者。有趣的是，Jon 和 P01 都保留了一些识别记忆能力，并且在功能磁共振成像期间显示出残余海马组织的激活。乔恩构建虚构和未来场景的能力与之前报告的这项任务和对照参与者的成人获得性病例进行了比较。与成人获得性病例相反，但与 P01 相似，乔恩能够以与对照参与者类似的方式丰富地想象虚构的和未来的经历。此外，他的建筑在空间上是连贯的。我们推测，之前在 P01 和 Jon 中注意到的功能磁共振成像期间的海马激活可能表明一些残余的海马功能足以支持他们保留想象虚构和未来情景的能力。
▶ Jon is a patient with developmental amnesia and bilateral hippocampal damage. ▶ Despite this, he is able to richly imagine fictitious and future scenarios. ▶ This is in contrast to most patients with adult-acquired amnesia. ▶ Residual hippocampal function may underpin preserved simulation ability. Patients with bilateral hippocampal damage acquired in adulthood who are amnesic for past events have also been reported to be impaired at imagining fictitious and future experiences. One such patient, P01, however, was found to be unimpaired on these tasks despite dense amnesia and 50% volume loss in both hippocampi. P01 might be an atypical case, and in order to investigate this we identified another patient with a similar neuropsychological profile. Jon is a well-characterised patient with developmental amnesia and 50% volume loss in his hippocampi. Interestingly both Jon and P01 retain some recognition memory ability, and show activation of residual hippocampal tissue during fMRI. Jon's ability to construct fictitious and future scenarios was compared with the adult-acquired cases previously reported on this task and control participants. In contrast to the adult-acquired cases, but similar to P01, Jon was able to richly imagine both fictitious and future experiences in a comparable manner to control participants. Moreover, his constructions were spatially coherent. We speculate that the hippocampal activation during fMRI noted previously in P01 and Jon might indicate some residual hippocampal function which is sufficient to support their preserved ability to imagine fictitious and future scenarios.
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影响因子：
15.9
作者：
de Haan, Michelle;Mishkin, Mortimer;Vargha-Khadem, Faraneh
通讯作者：
Vargha-Khadem, Faraneh
DOI：
10.1523/jneurosci.4549-07.2007
发表时间：
2007-12-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hassabis D;Kumaran D;Maguire EA
通讯作者：
Maguire EA
影响因子：
2.6
作者：
Crawford, JR;Garthwaite, PH
通讯作者：
Garthwaite, PH
影响因子：
2.6
作者：
Bird, Chris M.;Vargha-Khadem, Faraneh;Burgess, Neil
通讯作者：
Burgess, Neil
DOI：
10.1098/rstb.2001.0944
发表时间：
2001-09-29
影响因子：
6.3
作者：
Maguire, EA
通讯作者：
Maguire, EA