Sexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study.
Sexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study.
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脑复杂性、容量和一般智力之间的两性二态性关系(g)：一项跨队列研究。
DOI：
10.1038/s41598-022-15208-4
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发表时间：
2022-06-30
影响因子：
4.6
通讯作者：
Murray AD
中科院分区：
文献类型：
--
作者：
Sandu AL;Waiter GD;Staff RT;Nazlee N;Habota T;McNeil CJ;Chapko D;Williams JH;Fall CHD;Chandak GR;Pene S;Krishna M;McIntosh AM;Whalley HC;Kumaran K;Krishnaveni GV;Murray AD
据报道，在发育、衰老和不同病理过程中，大脑形态发生了变化。利用分形维数（FD）可以捕捉和量化脑回和脑沟形状复杂性所描述的脑形态。这种对大脑结构复杂性和脑容量的测量与智力有关，但对这些关系的两性二态性知之甚少。在本文中，性别差异的大脑结构复杂性和一般智力(g)之间的关系在两个不同的地理和文化人群（英国和印度）进行了调查。3D t1加权磁共振成像（MRI）数据和一系列认知测试来自三个不同队列的参与者：迈索尔帕台农队列（MPC）；50年代的阿伯丁儿童（ACONF）和英国生物银行。我们对每组进行了一系列认知测试，计算了MRI得出的大脑结构复杂性和g。大脑的复杂性和体积都与智力呈正相关，这种相关性在女性中很明显，但在男性中并不总是如此。这种关系可以在不同年龄和地理位置的人群中看到，并提高了对神经生物学性别差异的理解。
Changes in brain morphology have been reported during development, ageing and in relation to different pathologies. Brain morphology described by the shape complexity of gyri and sulci can be captured and quantified using fractal dimension (FD). This measure of brain structural complexity, as well as brain volume, are associated with intelligence, but less is known about the sexual dimorphism of these relationships. In this paper, sex differences in the relationship between brain structural complexity and general intelligence (g) in two diverse geographic and cultural populations (UK and Indian) are investigated. 3D T1-weighted magnetic resonance imaging (MRI) data and a battery of cognitive tests were acquired from participants belonging to three different cohorts: Mysore Parthenon Cohort (MPC); Aberdeen Children of the 1950s (ACONF) and UK Biobank. We computed MRI derived structural brain complexity and g estimated from a battery of cognitive tests for each group. Brain complexity and volume were both positively corelated with intelligence, with the correlations being significant in women but not always in men. This relationship is seen across populations of differing ages and geographical locations and improves understanding of neurobiological sex-differences.
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