The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis.
The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis.
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DOI：
10.1038/s41598-021-84573-3
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发表时间：
2021-03-04
影响因子：
4.6
通讯作者：
Wilson CA
中科院分区：
文献类型：
--
作者：
Rowland J;Wilson CA
越来越多的证据表明，母亲糖尿病在神经发育障碍的发病机制中起作用。然而，妊娠期糖尿病（GDM）与妊娠前糖尿病之间的特定关联一直没有得到很好的分离。因此，目的是系统地审查和荟萃分析文献有关的患病率和风险的两种神经发育障碍：自闭症谱系障碍（ASD）和注意缺陷多动障碍（ADHD），当暴露于GDM。系统检索PubMed、科克伦图书馆、EMBASE、PsycINFO和CINAHL中的合格文献，并进行正向和反向引文跟踪。由两名独立的评审员进行资格筛选、偏倚风险评估和数据提取。18项测量ASD的研究和15项测量ADHD的研究符合纳入标准。在荟萃分析中，ASD的风险增加（OR 1.42; 95% CI 1.22，1.65），但ADHD的风险没有增加（OR 1.01; 95% CI 0.79，1.28）。我们讨论这些不同风险的潜在机制。更好地了解这些神经发育障碍的风险因素，包括GDM和潜在机制，可能有助于为预防妊娠期间暴露于这些逆境的策略提供信息。
There is growing evidence for a role of maternal diabetes in the pathogenesis of neurodevelopmental disorders. However, the specific association between gestational diabetes (GDM), as opposed to pre-gestational diabetes, has been poorly isolated. Thus the aim was to systematically review and meta-analyse literature pertaining to prevalence and risk for two neurodevelopmental disorders: autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), when exposed to GDM. PubMed, Cochrane Library, EMBASE, PsycINFO and CINAHL were systematically searched for eligible literature, with forward and backward citation tracking. Screening for eligibility, risk of bias assessment and data extraction were performed by two independent reviewers. 18 studies measuring ASD and 15 measuring ADHD met inclusion criteria. On meta-analysis there was an increased risk of ASD (OR 1.42; 95% CI 1.22, 1.65) but not ADHD (OR 1.01; 95% CI 0.79, 1.28). We discuss potential mechanisms for these differing risks. Greater understanding of risk factors, including GDM, for these neurodevelopmental disorders and potential mechanisms may help inform strategies aimed at prevention of exposure to these adversities during pregnancy.
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影响因子：
3.9
作者：
Dodds, Linda;Fell, Deshayne B.;Bryson, Susan
通讯作者：
Bryson, Susan
影响因子：
5.2
作者：
Chien, Yi-Ling;Chou, Miao-Chun;Gau, Susan Shur-Fen
通讯作者：
Gau, Susan Shur-Fen
影响因子：
0.7
作者：
Kania, Michal;Herbut, Katarzyna;Kozek, Elzbieta
通讯作者：
Kozek, Elzbieta
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
6.9
作者：
Baxter, A. J.;Brugha, T. S.;Scott, J. G.
通讯作者：
Scott, J. G.