Prenatal cocaine exposure and gray matter volume in adolescent boys and girls: relationship to substance use initiation.
Prenatal cocaine exposure and gray matter volume in adolescent boys and girls: relationship to substance use initiation.
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DOI：
10.1016/j.biopsych.2013.04.030
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发表时间：
2013-10-01
影响因子：
10.6
通讯作者：
Sinha, Rajita
中科院分区：
文献类型：
--
作者：
Rando, Kenneth;Chaplin, Tara M.;Potenza, Marc N.;Mayes, Linda;Sinha, Rajita
关键词：
关于产前可卡因暴露的研究主要研究儿童人群。研究青少年尤其重要，因为青春期是改变动机和开始使用药物的时期。使用磁共振成像和全脑体素为基础的形态测量，我们评估了42个产前可卡因暴露（PCE）和21个非可卡因暴露（NCE）的青少年，年龄在14至17岁的灰质体积（GMV）的差异。研究了显着聚类中GMV差异与物质使用开始概率之间的关联。PCE相对于NCE青少年表现出三组较低的GMV，涉及边缘系统和边缘系统（p <0.001，FWE校正）、上级额回（p = 0.001，FWE校正）和楔前叶（p = 0.019，FWE校正）。上级额叶和楔前叶群的GMV与物质使用的开始相关。GMV每减少1 mL，在上级额叶簇和楔前叶簇中开始使用药物的概率分别增加69.6%（p = .01）和83.6%（p = .02）。PCE与皮质和边缘区域的结构差异有关。额叶皮质和后部区域的较低GMV与物质使用开始相关，可能代表物质使用的生物风险标志物。
Studies of prenatal cocaine exposure have primarily examined childhood populations. Studying adolescents is especially important because adolescence is a time of changing motivations and initiation of substance use. Using magnetic resonance imaging and whole-brain voxel-based morphometry, we assessed gray matter volume (GMV) differences in 42 prenatally cocaine exposed (PCE) and 21 noncocaine-exposed (NCE) adolescents, aged 14 to 17 years. Associations between GMV differences in significant clusters and the probability of substance use initiation were examined. PCE relative to NCE adolescents demonstrated three clusters of lower GMV involving a limbic and paralimbic (p < .001, family-wise error [FWE] corrected), superior frontal gyrus (p = .001, FWE corrected), and precuneus (p = .019, FWE corrected) cluster. GMVs in the superior frontal and precuneus clusters were associated with initiation of substance use. Each 1-mL decrease in GMV increased the probability of initiating substance use by 69.6% (p = .01) in the superior frontal cluster and 83.6% (p = .02) in the precuneus cluster. PCE is associated with structural differences in cortical and limbic regions. Lower GMVs in frontal cortical and posterior regions are associated with substance use initiation and may represent biological risk markers for substance use.
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影响因子：
14.5
作者：
Berlin, HA;Rolls, ET;Kischka, U
通讯作者：
Kischka, U
DOI：
10.1016/j.jaac.2010.08.017
发表时间：
2010-12
影响因子：
13.3
作者：
Casey BJ;Jones RM
通讯作者：
Jones RM
影响因子：
2.9
作者：
Delaney-Black, Virginia;Chiodo, Lisa M.;Hannigan, John H.;Greenwald, Mark K.;Janisse, James;Patterson, Grace;Huestis, Marilyn A.;Partridge, Robert T.;Ager, Joel;Sokol, Robert J.
通讯作者：
Sokol, Robert J.
影响因子：
3.4
作者：
Colder, CR;Chassin, L
通讯作者：
Chassin, L
影响因子：
3.8
作者：
Avants, Brian B.;Hurt, Hallam;Gee, James C.
通讯作者：
Gee, James C.