Innate Immune Receptors as Competitive Determinants of Cell Fate.
Innate Immune Receptors as Competitive Determinants of Cell Fate.
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DOI：
10.1016/j.molcel.2017.05.009
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发表时间：
2017-06-15
期刊：
影响因子：
16
通讯作者：
Kagan JC
中科院分区：
文献类型：
--
作者：
Franz KM;Kagan JC
感染会对宿主和微生物造成多种压力。为了检测潜在的感染，哺乳动物的免疫系统利用几个模式识别受体家族，它们调查微生物产品的细胞内和细胞外环境。每个受体家族的成员都会诱导抗微生物效应反应，包括炎性细胞因子或干扰素的表达，蛋白质合成的下调或宿主细胞的死亡。在这篇综述中，我们讨论了每一种先天免疫反应的好处。我们强调非传染性细菌和病毒通常如何激活单个受体家族，从而导致可预测的宿主反应。相比之下，感染强毒病原体可能会激活来自不同家族的受体。由于每个受体家族可能会诱导与另一个家族的活动相互拮抗或协同的反应，因此在致病过程中细胞命运的决定是不可预测的。了解先天免疫系统的拮抗抗微生物活性应该有助于深入了解细胞命运是如何在感染期间以及潜在的其他环境压力期间做出的。Franz等人描述了在各种类型的微生物接触中，先天免疫受体如何控制宿主细胞的命运决定。在感染期间，多个受体识别相同的微生物配体，但这些受体可以诱导相互对抗的细胞反应。受体之间的这种竞争决定了宿主细胞在感染期间的命运决定。
Infections can cause a multitude of stresses on the host and microbe. To detect potential infections, the mammalian immune system utilizes several families of pattern recognition receptors, which survey the intracellular and extracellular environments for microbial products. Members of each receptor family induce antimicrobial effector responses, which include inflammatory cytokine or interferon expression, downregulation of protein synthesis or host cell death. In this Review, we discuss the benefits of each of these innate immune responses. We highlight how non-infectious bacteria and viruses typically activate a single family of receptors, which results in a predictable host response. Infections with virulent pathogens, in contrast, may activate receptors from distinct families. As each receptor family may induce responses that antagonize or synergize with the activities of another family, cell fate decisions during pathogenic encounters are unpredictable. Understanding the antagonistic antimicrobial activities of the innate immune system should provide insight into how cell fate decisions are made during infections, and potentially during other environmental stresses. Franz et al describe how innate immune receptors control host cell fate decisions during various types of microbial encounters. During infections, multiple receptors recognize the same microbial ligand, but these receptors can induce cellular responses that antagonize each other. This competition among receptors determines host cell fate decisions during infection.
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DOI：
10.1016/j.trsl.2008.12.005
发表时间：
2009-04
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Fu P;Birukov KG
通讯作者：
Birukov KG
影响因子：
8.7
作者：
Elliott EI;Sutterwala FS
通讯作者：
Sutterwala FS
影响因子：
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Brubaker SW;Bonham KS;Zanoni I;Kagan JC
通讯作者：
Kagan JC
影响因子：
100.3
作者：
Blander, J. Magarian;Sander, Leif E.
通讯作者：
Sander, Leif E.
细菌效应器设计和功能的常见主题。
影响因子：
30.3
作者：
Galan, Jorge E.
通讯作者：
Galan, Jorge E.