Circulating magnesium levels and incidence of coronary heart diseases, hypertension, and type 2 diabetes mellitus: a meta-analysis of prospective cohort studies.
Circulating magnesium levels and incidence of coronary heart diseases, hypertension, and type 2 diabetes mellitus: a meta-analysis of prospective cohort studies.
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DOI：
10.1186/s12937-017-0280-3
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发表时间：
2017-09-19
影响因子：
5.4
通讯作者：
He K
中科院分区：
文献类型：
--
作者：
Wu J;Xun P;Tang Q;Cai W;He K
关于循环镁 (Mg) 水平与冠心病 (CHD)、高血压和 2 型糖尿病 (T2DM) 发病率之间关系的数据不一致且不确定。本研究的目的是检查循环镁水平与 CHD、高血压和 T2DM 发病率的关系。通过 PubMed、EmBase、SCOPUS 和 Google Scholar 检索 2017 年 5 月之前发表的前瞻性队列研究。共有 11 项研究报告了经过多变量调整后的相关关联。提取并分析了有关研究和参与者的特征、暴露、主要结果、风险估计和联合创始人的信息。在 11 项纳入的研究中，5 项报告了 CHD 的结果（38,808 名受试者[4437 例]，平均随访 10.5 年），3 项报告高血压结果（14,876 名受试者[3149 例]，随访 6.7 年），4 项报告 T2DM 的结果（31,284 名受试者[2680 例]，平均随访 8.8 年）。比较最高和最低循环镁浓度类别，CHD、高血压和 T2DM 发病率的汇总相对风险 [RR]（95% 置信区间 [CI]）分别为 0.86（0.74，0.996）、0.91（0.80，1.02）和 0.64（0.50，0.81）。循环镁水平每增加 0.1 mmol/L，高血压发病率就会降低 4%（RR，0.96；95% CI：0.94，0.99）。循环镁水平与 CHD（RR，0.89；95% CI：0.77，1.03）和 T2DM（RR，0.90；95% CI：0.81，1.002）的发病率之间没有发现显着的线性相关性。观察到的感兴趣的关联对于排除个别研究很敏感。这项荟萃分析的结果表明，循环镁水平与 CHD、高血压和 T2DM 的发病率呈负相关。需要更多的研究来提供更确凿的证据，并确定对于 CHD、高血压和 T2DM 一级预防的最佳循环镁浓度范围。本文的在线版本 (10.1186/s12937-017-0280-3) 包含补充材料，可供授权用户使用。
Data on the associations between circulating magnesium (Mg) levels and incidence of coronary heart diseases (CHD), hypertension, and type 2 diabetes mellitus (T2DM) are inconsistent and inconclusive. The aim of this study was to examine circulating Mg levels in relation to incidence of CHD, hypertension, and T2DM. Prospective cohort studies published before May 2017 were searched through PubMed, EmBase, SCOPUS, and Google Scholar. A total of 11 studies that reported multivariable-adjusted associations of interest were identified. Information on the characteristics of study and participants, exposure, main outcomes, risk estimates, and cofounders was extracted and analyzed. Of the 11 included studies, 5 reported results on CHD (38,808 individuals [4437 cases] with an average 10.5-year follow-up), 3 on hypertension (14,876 participants [3149 cases] with a 6.7-year follow-up), and 4 on T2DM (31,284 participants [2680 cases] with an 8.8-year follow-up). Comparing the highest to the lowest category of circulating Mg concentration, the pooled relative risks [RRs] (95% confidence intervals [CIs]) were 0.86 (0.74, 0.996), 0.91 (0.80, 1.02), and 0.64 (0.50, 0.81) for incidence of CHD, hypertension, and T2DM, respectively. Every 0.1 mmol/L increment in circulating Mg levels was associated with 4% (RR, 0.96; 95% CI: 0.94, 0.99) reduction in hypertension incidence. No significant linear association was found between circulating Mg levels and incidence of CHD (RR, 0.89; 95% CI: 0.77, 1.03) and T2DM (RR, 0.90; 95% CI: 0.81, 1.002). The observed associations of interest were sensitive to exclusion of individual studies. Findings in this meta-analysis suggest that circulating Mg levels are inversely associated with incidence of CHD, hypertension, and T2DM. Additional studies are needed to provide more solid evidence and identify the optimal range of circulating Mg concentration with respect to primary prevention of CHD, hypertension, and T2DM. The online version of this article (10.1186/s12937-017-0280-3) contains supplementary material, which is available to authorized users.
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影响因子：
5.1
作者：
Guariguata, L.;Whiting, D. R.;Shaw, J. E.
通讯作者：
Shaw, J. E.
影响因子：
4.7
作者：
通讯作者：
--
膳食镁摄入量与心血管疾病、2型糖尿病和全因死亡率的风险：前瞻性队列研究的剂量反应荟萃分析
影响因子：
9.3
作者：
Fang X;Wang K;Han D;He X;Wei J;Zhao L;Imam MU;Ping Z;Li Y;Xu Y;Min J;Wang F
通讯作者：
Wang F
DOI：
10.1111/j.1365-2362.2008.01957.x
发表时间：
2008-06-01
影响因子：
5.5
作者：
Guerrero-Romero, F.;Rascon-Pacheco, R. A.;Wacher, N.
通讯作者：
Wacher, N.
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP