CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.
CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.
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DOI：
10.1186/1756-6606-6-41
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发表时间：
2013-09-23
期刊：
影响因子：
3.6
通讯作者：
Higashida H
中科院分区：
文献类型：
--
作者：
Akther S;Korshnova N;Zhong J;Liang M;Cherepanov SM;Lopatina O;Komleva YK;Salmina AB;Nishimura T;Fakhrul AA;Hirai H;Kato I;Yamamoto Y;Takasawa S;Okamoto H;Higashida H
哺乳动物公畜参与婴儿护理。我们以前证明了一种非一夫一妻制的实验室小鼠品系的父系在新环境中隔离期间响应来自母体的嗅觉和听觉信号而启动亲本检索行为。当公鹿单独关在笼子里时，这种行为在没有这种信号的情况下很快就会消失。控制父亲行为的神经回路和激素还没有得到很好的理解。CD 38是一种膜糖蛋白，催化环ADP-核糖的合成，并促进催产素（OT）分泌，这是由于下丘脑中催产素能神经元胞浆游离钙浓度的环ADP-核糖依赖性增加。在本文中，我们研究了CD 38在脑桥核（NAcc）和OT对父亲的幼崽检索行为的作用，使用CD 38基因敲除（CD 38 −/−）小鼠的ICR品系。在新笼中与交配母鼠隔离10分钟后，CD 38 −/−公驴与其幼仔团聚时，未能恢复，但与幼仔无关。当与经OT处理的CD 38 −/−母鼠一起笼中时，经单次皮下注射OT处理的CD 38 −/−公驴在恢复事件中表现出恢复。我们使用慢病毒感染技术将人CD 38引入CD 38 −/−受体的NAcc中，并检查了CD 38局部表达的影响。用OT和在NAcc中表达CD 38的公畜处理的敲除母畜对显示出更多的恢复（野生型公畜水平的83%）。在NAcc中表达CD 38的母猪中，结合OT给药获得了完全恢复的恢复。其他父系行为，包括梳理幼崽、蹲伏和蜷缩，在NAcc中表达CD 38的CD 38 −/−公畜中也比在NAcc中不表达CD 38的CD 38 −/−公畜中更常见。NAcc和OT中的CD 38在父性行为中至关重要。
Mammalian sires participate in infant care. We previously demonstrated that sires of a strain of nonmonogamous laboratory mice initiate parental retrieval behavior in response to olfactory and auditory signals from the dam during isolation in a new environment. This behavior is rapidly lost in the absence of such signals when the sires are caged alone. The neural circuitry and hormones that control paternal behavior are not well-understood. CD38, a membrane glycoprotein, catalyzes synthesis of cyclic ADP-ribose and facilitates oxytocin (OT) secretion due to cyclic ADP-ribose-dependent increases in cytosolic free calcium concentrations in oxytocinergic neurons in the hypothalamus. In this paper, we studied CD38 in the nucleus accumbens (NAcc) and the role of OT on paternal pup retrieval behavior using CD38 knockout (CD38−/−) mice of the ICR strain. CD38−/− sires failed to retrieve when they were reunited with their pups after isolation together with the mate dams, but not with pup, in a novel cage for 10 min. CD38−/− sires treated with a single subcutaneous injection of OT exhibited recovery in the retrieval events when caged with CD38−/− dams treated with OT. We introduced human CD38 in the NAcc of CD38−/− sires using a lentiviral infection technique and examined the effects of local expression of CD38. Pairs of knockout dams treated with OT and sires expressing CD38 in the NAcc showed more retrieval (83% of wild-type sire levels). Complete recovery of retrieval was obtained in sires with the expression of CD38 in the NAcc in combination with OT administration. Other paternal behaviors, including pup grooming, crouching and huddling, were also more common in CD38−/− sires with CD38 expression in the NAcc compared with those in CD38−/− sires without CD38 expression in the NAcc. CD38 in the NAcc and OT are critical in paternal behavior.
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