Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort.
Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort.
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DOI：
10.1371/journal.pone.0128891
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Krogh V
中科院分区：
文献类型：
--
作者：
Agnoli C;Grioni S;Sieri S;Sacerdote C;Ricceri F;Tumino R;Frasca G;Pala V;Mattiello A;Chiodini P;Iacoviello L;De Curtis A;Panico S;Krogh V
代谢综合征（定义为腹部肥胖、高血甘油三酯、低高密度脂蛋白胆固醇、高血糖和高血压中的至少三种）正在成为乳腺癌的危险因素;然而，很少有研究（大多数仅限于绝经后妇女）调查乳腺癌风险和代谢综合征之间的关系。本研究的目的是探讨绝经后和绝经前妇女代谢综合征及其组分与乳腺癌风险之间的关系。我们对1993 - 1998年在欧洲癌症与营养前瞻性调查（EPIC）的四个意大利中心（都灵、瓦雷塞、那不勒斯、拉古萨）招募的22,494名妇女进行了病例队列研究，并随访长达15年。一个随机的子队列的565名妇女和593例乳腺癌被诊断。通过Prentice加权考克斯比例风险模型估计风险比（HR）和95%置信区间（CI），调整潜在混杂因素。在所有女性中，代谢综合征的存在与乳腺癌风险显著增加相关（HR 1.52，95%CI 1.14 - 2.02）。当对绝经状态单独重复分析时，这种关联仅限于绝经后妇女（HR 1.80，95%CI 1.22 - 2.65），而在绝经前妇女中不存在（HR 0.71，95%CI 0.43 - 1.16）;代谢综合征和绝经状态之间相互作用的P值为0.001。在代谢综合征中，只有高血糖与所有女性（HR 1.47，95%CI 1.13 - 1.91）和绝经后女性（HR 1.89，95%CI 1.29 - 2.77）乳腺癌风险增加显著相关，但与绝经前女性无关（HR 0.80，95%CI 0.52 - 1.22; P相互作用= 0.004）。这些发现支持了先前的数据，表明代谢综合征是绝经后妇女乳腺癌的重要危险因素，但不是绝经前妇女，并表明通过改变生活方式预防代谢综合征可以保护乳腺癌。
Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, low high-density lipoprotein cholesterol, high blood glucose, and high blood pressure) is emerging as a risk factor for breast cancer; however few studies – most confined to postmenopausal women – have investigated associations between breast cancer risk and metabolic syndrome. The purpose of this study was to examine the association between metabolic syndrome and its components, and risk of breast cancer in postmenopausal and premenopausal women. We performed a case-cohort study on 22,494 women recruited in 1993-1998 to four Italian centres (Turin, Varese, Naples, Ragusa) of the European Prospective Investigation into Cancer and Nutrition (EPIC) and followed-up for up to 15 years. A random subcohort of 565 women was obtained and 593 breast cancer cases were diagnosed. Hazard ratios (HR) with 95% confidence intervals (CI), adjusted for potential confounders, were estimated by Prentice-weighted Cox proportional hazards models. Presence of metabolic syndrome was associated with significantly increased breast cancer risk in all women (HR 1.52, 95%CI 1.14-2.02). When the analyses were repeated separately for menopausal status, the association was limited to postmenopausal women (HR 1.80, 95%CI 1.22-2.65) and absent in premenopausal women (HR 0.71, 95%CI 0.43-1.16); P for interaction between metabolic syndrome and menopausal status was 0.001. Of metabolic syndrome components, only high blood glucose was significantly associated with increased breast cancer risk in all women (HR 1.47, 95%CI 1.13-1.91) and postmenopausal women (HR 1.89, 95%CI 1.29-2.77), but not premenopausal women (HR 0.80, 95%CI 0.52-1.22; P interaction=0.004). These findings support previous data indicating that metabolic syndrome is an important risk factor for breast cancer in postmenopausal women, but not in premenopausal women, and suggest that prevention of metabolic syndrome through lifestyle changes could confer protection against breast cancer.
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DOI：
10.1016/j.numecd.2009.02.006
发表时间：
2010-01
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
通讯作者：
Krogh V
DOI：
10.1158/1055-9965.epi-09-0235
发表时间：
2009-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kabat GC;Kim M;Chlebowski RT;Khandekar J;Ko MG;McTiernan A;Neuhouser ML;Parker DR;Shikany JM;Stefanick ML;Thomson CA;Rohan TE
通讯作者：
Rohan TE
影响因子：
4.7
作者：
Norat, T.;Dossus, L.;Kaaks, R.
通讯作者：
Kaaks, R.
影响因子：
4.9
作者：
McTernan, PG;Anwar, A;Kumar, S
通讯作者：
Kumar, S
影响因子：
3.8
作者：
Bosco, Jaclyn L. F.;Palmer, Julie R.;Boggs, Deborah A.;Hatch, Elizabeth E.;Rosenberg, Lynn
通讯作者：
Rosenberg, Lynn