Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion.
Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion.
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DOI：
10.1038/s41598-021-99572-7
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发表时间：
2021-10-08
影响因子：
4.6
通讯作者：
Terasaki H
中科院分区：
文献类型：
--
作者：
Tomita R;Iwase T;Fukami M;Goto K;Ra E;Terasaki H
采用激光散斑血流图（LSFG）对32例（32只眼）视网膜静脉阻塞（BRVO）患者的分支病变区视网膜动脉的电阻率进行了测量。检查视网膜动脉和静脉运行到BRVO受影响的区域和垂直对称的血管在未受影响的地区。我们应用LSFG参数搏动强度与平均模糊率（BOM），使用与多普勒血流仪中使用的脉动指数相似的方法计算，以评估血管的电阻率。我们的研究结果表明，BOM地图可以清楚地可视化电阻率的增加，在视网膜动脉作为一个二维地图。病变区动脉BOM显著高于非病变区（P = 0.001）。多元回归分析显示，视网膜出血区视网膜动脉BOM与正常视网膜动脉BOM的比值与视网膜出血的程度显著相关（β = 0.447，P = 0.009）。总之，BRVO影响区域的视网膜动脉电阻率指数较高，可以在二维图中可视化。这些发现和技术将有助于阐明BRVO的病理生理机制。
We aimed to investigate the increase in resistivity of the retinal artery in the branch retinal vein occlusion (BRVO)-affected area, and to visualize it. Thirty-two eyes of 32 patients with BRVO were measured by laser speckle flowgraphy (LSFG). The retinal artery and vein running to the BRVO-affected area and vertically symmetrical vessels in the unaffected area were examined. We applied the LSFG parameter beat strength over mean blur rate (BOM), calculated using a similar method to the pulsatility index used in Doppler flowmetry to evaluate resistivity of the vessels. Our results showed that the BOM map could clearly visualize the increase of resistivity in the retinal artery as a two-dimensional map. The BOM of the arteries in the affected area was significantly higher than that of the unaffected area (P = 0.001). Multiple regression analysis showed that the ratio of BOM in retinal arteries of the affected area to the unaffected was significantly associated with the extent of retinal hemorrhage (β = 0.447, P = 0.009). In conclusion, the index of resistivity of the retinal artery in the BRVO-affected area was higher and could be visualized in a two-dimensional map. These findings and techniques would contribute to elucidate the pathophysiology of BRVO.
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DOI：
10.1900/rds.2012.9.104
发表时间：
2012-06-01
期刊：
The review of diabetic studies : RDS
影响因子：
--
作者：
Karami, Mehdi;Janghorbani, Mohsen;Kaviani, Ahmad
通讯作者：
Kaviani, Ahmad
影响因子：
4.2
作者：
Yoshida, A;Feke, GT;McMeel, JW
通讯作者：
McMeel, JW
影响因子：
3
作者：
Matsumoto M;Suzuma K;Akiyama F;Yamada K;Harada S;Tsuiki E;Kitaoka T
通讯作者：
Kitaoka T
影响因子：
13.7
作者：
Wong, TY;Larsen, EKM;Sharrett, AR
通讯作者：
Sharrett, AR
影响因子：
4.1
作者：
Arsène, S;Giraudeau, B;Tranquart, F
通讯作者：
Tranquart, F