Rational design of hydrogels to enhance osteogenic potential.
Rational design of hydrogels to enhance osteogenic potential.
复制标题
水凝胶的合理设计以增强成骨潜力。
DOI：
10.1021/acs.chemmater.0c03018
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发表时间：
2020-11-24
期刊：
影响因子：
--
通讯作者：
Lee M
中科院分区：
文献类型：
--
作者：
Kim S;Lee M
骨组织工程（BTE）包括生物材料，细胞和生物活性分子的领域，以成功地引导骨组织的生长和修复。目前的BTE策略依赖于通过支架材料递送成骨分子或细胞。然而，基于生长因子和干细胞的治疗有几个局限性，例如来源限制、稳定性低、难以预测长期疗效和高成本等。这些问题促进了基于材料的治疗的发展，其具有可接近性、高稳定性、可调节的功效和低成本生产的特性。水凝胶因其独特的亲水性和可调节的物理化学性质而广泛用于BTE应用，以模拟天然骨环境。然而，目前的水凝胶材料不是理想的候选者，因为它们自身的成骨能力很小。因此，最近的研究BTE水凝胶试图平衡这些问题，通过修改其生物物理特性。在这篇文章中，我们回顾了最近的进展，在水凝胶的设计，以指导成骨潜力，并提出了策略，以精确控制其骨愈合性能。
Bone tissue engineering (BTE) encompasses the field of biomaterials, cells, and bioactive molecules to successfully guide the growth and repair of bone tissue. Current BTE strategies rely on delivering osteogenic molecules or cells via scaffolding materials. However, growth factor- and stem cell-based treatments have several limitations, such as source restriction, low stability, difficulties in predicting long-term efficacy, and high costs, among others. These issues have promoted the development of material-based therapy with properties of accessibility, high stability, tunable efficacy, and low-cost production. Hydrogels are widely used in BTE applications because of their unique hydrophilic nature and tunable physicochemical properties to mimic the native bone environment. However, current hydrogel materials are not ideal candidates due to minimal osteogenic capability on their own. Therefore, recent studies of BTE hydrogels attempt to counterbalance these issues by modifying their biophysical properties. In this article, we review recent progress in the design of hydrogels to instruct osteogenic potential, and present strategies developed to precisely control its bone healing properties.
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