A pilot quantitative study of topographic correlation between reticular pseudodrusen and the choroidal vasculature using en face optical coherence tomography.
A pilot quantitative study of topographic correlation between reticular pseudodrusen and the choroidal vasculature using en face optical coherence tomography.
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DOI：
10.1371/journal.pone.0092841
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fawzi AA
中科院分区：
文献类型：
--
作者：
Grewal DS;Chou J;Rollins SD;Fawzi AA
目的：应用面视容积光谱域光学相干断层扫描（SD-OCT）分析红外线反射（IR）显示的网状假性玻璃疣（RPD）与脉络膜血管之间的地形相关性。设盲的观察者使用ImageJ（NIH，Bethesda，MD）在IR图像上标记个体RPD。使用黄斑体积扫描（Cirrus，Carl Zeiss Meditec Inc，都柏林，CA），使用RPE平板功能生成最浅表脉络膜血管系统的C扫描。一个独立的蒙面分级创建脉络膜血管的地形二进制地图阈值的正面图像，这是覆盖到RPD的IR地图。对于每个IR图像，ImageJ用于生成一组随机点作为"对照病变"。本文分析了11例（78 ± 13.7岁）RPD患者的17只眼。在IR图像上识别的RPD病变的平均数量为414 ± 71.5，其中49.6 ± 4.3%位于脉络膜血管上，而对照组为45.4 ± 4.0%（p = 0.014）。 50.4 ± 4.3%的病变覆盖脉络膜基质，其中76.5 ± 3.1%的病变距离脉络膜血管≤ 3个像素。距离脉络膜血管≤ 3像素内的RPD病变百分比显著大于距离≥ 7像素的百分比。（p <0.0001）。与对照组（71.6 ± 3.8%）相比，RPD更可能位于距离脉络膜血管≤ 3像素处（p = 0.014）。 相比之下，对照病变距离脉络膜血管≥ 7像素的可能性高于RPD（分别为9.1 ± 1.9% vs. 4.8 ± 1.2%，p = 0.002）。 我们的分析表明，RPD病变遵循的基础脉络膜血管。大约一半的RPD直接覆盖脉络膜血管，其余大部分病变距离血管边缘≤ 3像素（≤ 30微米），支持RPD可能与脉络膜水平的病理变化相关的假设。
To analyze the topographic correlation between reticular pseudodrusen (RPD) visualized on infrared reflectance (IR) and choroidal vasculature using en-face volumetric spectral-domain optical coherence tomography (SD-OCT). A masked observer marked individual RPD on IR images using ImageJ (NIH, Bethesda, MD). Using the macular volume scan (Cirrus, Carl Zeiss Meditec Inc, Dublin, CA), the RPE slab function was used to generate a C-scan of the most superficial choroidal vasculature. An independent masked grader created a topographic binary map of the choroidal vasculature by thresholding the en-face image, which was overlaid onto the IR map of RPD. For each IR image, ImageJ was used to generate a random set of dots as “control lesions”. 17 eyes of 11 patients (78±13.7 years) with RPD were analyzed. The average number of RPD lesions identified on IR images was 414±71.5, of which 49.6±4.3% were located overlying the choroidal vasculature, compared to 45.4±4.0% in controls (p = 0.014). 50.4±4.3% of lesions overlay the choroidal stroma, of which 76.5±3.1% were ≤3 pixels from the choroidal vessels. The percentage of RPD lesions located within ≤3 pixels from the choroidal vasculature was significantly greater than the percentage located ≥7 pixels away. (p<0.0001). Compared to controls (71.6±3.8%), RPD were more likely to be located ≤3 pixels away from choroidal vessels (p = 0.014). In contrast, control lesions were more likely to be ≥7 pixels away from choroidal vessels than RPD (9.1±1.9% vs. 4.8±1.2%, respectively, p = 0.002). Our analysis shows that RPD lesions follow the underlying choroidal vasculature. Approximately half the RPD directly overlay the choroidal vessels and the majority of the remaining lesions were ≤3 pixels (≤30microns) from the vessel edge, supporting the hypothesis that RPD maybe related to pathologic changes at the choroidal level.
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影响因子：
3.4
作者：
Rudolf, Martin;Malek, Goldis;Messinger, Jeffrey D.;Clark, Mark E.;Wang, Lan;Curcio, Christine A.
通讯作者：
Curcio, Christine A.
影响因子：
4.4
作者：
McLeod DS;Grebe R;Bhutto I;Merges C;Baba T;Lutty GA
通讯作者：
Lutty GA
影响因子：
4.2
作者：
Klein, Ronald;Meuer, Stacy M.;Klein, Barbara E. K.
通讯作者：
Klein, Barbara E. K.
DOI：
10.1097/00006982-199515030-00001
发表时间：
1995-01-01
影响因子：
3.3
作者：
ARNOLD, JJ;SARKS, SH;SARKS, JP
通讯作者：
SARKS, JP
影响因子：
3.4
作者：
Jaillon F;Makita S;Min EJ;Lee BH;Yasuno Y
通讯作者：
Yasuno Y