Neurologic abnormalities in workers of a 1-bromopropane factory.
Neurologic abnormalities in workers of a 1-bromopropane factory.
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1-溴丙烷工厂工人的神经系统异常。
DOI：
10.1289/ehp.6995
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发表时间：
2004-09
影响因子：
10.4
通讯作者：
Takeuchi Y
中科院分区：
文献类型：
--
作者：
Ichihara G;Li W;Shibata E;Ding X;Wang H;Liang Y;Peng S;Itohara S;Kamijima M;Fan Q;Zhang Y;Zhong E;Wu X;Valentine WM;Takeuchi Y
我们最近报道了1-溴丙烷(1-BP； n-丙基溴，CAS登记号：106-94-5)是一种臭氧消耗溶剂的替代品，对大鼠具有神经毒性和生殖毒性。最近的四个病例报告表明1-BP对工人可能有神经毒性。本研究的目的是建立1-BP对工人的神经系统影响，并检查其与暴露水平的关系。我们调查了一家1-BP生产工厂的27名女工，并将其中23名女工与一家啤酒厂的23名年龄相当的工人作为对照。通过神经学、电生理、血液学、生化、神经行为学和体位摇摆测试对工人进行访谈和检查。使用被动采样器估计1-BP暴露水平。用音叉进行的测试显示，接触1-BP的15名工人的足部振动感觉减弱，而对照组则没有。1-BP工厂工人胫神经远端潜伏期明显长于对照组，但运动神经传导速度无显著变化。与年龄和受教育程度相匹配的对照组相比，工作人员在腓肠神经感觉神经传导速度、向后回忆数字、本顿视觉记忆测试分数、追求瞄准测试分数以及情绪状态测试（POMS）的五个项目（紧张、抑郁、焦虑、疲劳和困惑）方面也表现出较低的值。1999年5月以后入职的工人，只暴露在1-BP环境中（1999年以前入职的工人也可能暴露在2-BP环境中），在振动感、远端潜伏期、Benton测试分数、POMS测试中抑郁和疲劳表现出相似的变化。工人的时间加权平均暴露水平为0.34-49.19 ppm。暴露于1-BP可能对周围神经或/和中枢神经系统产生不良影响。
We reported recently that 1-bromopropane (1-BP; n-propylbromide, CAS Registry no. 106-94-5), an alternative to ozone-depleting solvents, is neurotoxic and exhibits reproductive toxicity in rats. The four most recent case reports suggested possible neurotoxicity of 1-BP in workers. The aim of the present study was to establish the neurologic effects of 1-BP in workers and examine the relationship with exposure levels. We surveyed 27 female workers in a 1-BP production factory and compared 23 of them with 23 age-matched workers in a beer factory as controls. The workers were interviewed and examined by neurologic, electrophysiologic, hematologic, biochemical, neurobehavioral, and postural sway tests. 1-BP exposure levels were estimated with passive samplers. Tests with a tuning fork showed diminished vibration sensation of the foot in 15 workers exposed to 1-BP but in none of the controls. 1-BP factory workers showed significantly longer distal latency in the tibial nerve than did the controls but no significant changes in motor nerve conduction velocity. Workers also displayed lower values in sensory nerve conduction velocity in the sural nerve, backward recalled digits, Benton visual memory test scores, pursuit aiming test scores, and five items of the Profile of Mood States (POMS) test (tension, depression, anxiety, fatigue, and confusion) compared with controls matched for age and education. Workers hired after May 1999, who were exposed to 1-BP only (workers hired before 1999 could have also been exposed to 2-BP), showed similar changes in vibration sense, distal latency, Benton test scores, and depression and fatigue in the POMS test. Time-weighted average exposure levels in the workers were 0.34–49.19 ppm. Exposure to 1-BP could adversely affect peripheral nerves or/and the central nervous system.
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影响因子：
3
作者：
Ichihara, G;Miller, JK;Takeuchi, Y
通讯作者：
Takeuchi, Y
影响因子：
3.5
作者：
Ichihara, G;Li, WH;Takeuchi, Y
通讯作者：
Takeuchi, Y
影响因子：
3.8
作者：
Ichihara, G;Kitoh, J;Takeuchi, Y
通讯作者：
Takeuchi, Y
影响因子：
3.4
作者：
Wang, HL;Ichihara, G;Takeuchi, Y
通讯作者：
Takeuchi, Y
影响因子：
3.5
作者：
ESCALONA, E;YANES, L;MAIZLISH, N
通讯作者：
MAIZLISH, N