Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China.

Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China.
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中国广东省自然群体中具有 3 个重组区的 1 型重组登革热病毒的鉴定。

DOI:
10.1007/s00705-008-0090-1
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发表时间:
2008
影响因子:
2.7
通讯作者:
Qin ED
Qin ED
中科院分区:
医学4区
文献类型:
--
作者:
Chen SP;Yu M;Jiang T;Deng YQ;Qin CF;Han JF;Qin ED

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利用重组分析,我们确定了一个重组登革病毒1型株,即GD 23/95,具有三个重组区,分别位于prM/E连接,NS 1和NS 3的序列。根据重组区和非重组区进行系统发育分析,进一步证实了重组登革病毒。这似乎是第一个研究,以确认在一个单一的登革病毒分离株中存在三个重组区域,并报告从同一地理区域(广东省,中国)分离的亲本病毒株之间的重组。它也是第一个报告登革热病毒NS 3基因内的断点。
Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively. The recombinant dengue virus was further confirmed by phylogenetic analysis based on its recombination and non-recombination regions. This appears to be the first study to confirm the existence of three recombination regions in a single dengue virus isolate and to report recombination between parent virus strains isolated from the same geographic area (Guangdong province, China). It is also the first to report breakpoints within the NS3 gene of dengue viruses.
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