Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China.
Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China.
复制标题
中国广东省自然群体中具有 3 个重组区的 1 型重组登革热病毒的鉴定。
DOI:
10.1007/s00705-008-0090-1
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发表时间:
2008
影响因子:
2.7
通讯作者:
Qin ED
中科院分区:
文献类型:
--
作者:
Chen SP;Yu M;Jiang T;Deng YQ;Qin CF;Han JF;Qin ED
Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively. The recombinant dengue virus was further confirmed by phylogenetic analysis based on its recombination and non-recombination regions. This appears to be the first study to confirm the existence of three recombination regions in a single dengue virus isolate and to report recombination between parent virus strains isolated from the same geographic area (Guangdong province, China). It is also the first to report breakpoints within the NS3 gene of dengue viruses.
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