Estimating Environmental Hazard and Risks from Exposure to Per- and Polyfluoroalkyl Substances (PFASs): Outcome of a SETAC Focused Topic Meeting.
Estimating Environmental Hazard and Risks from Exposure to Per- and Polyfluoroalkyl Substances (PFASs): Outcome of a SETAC Focused Topic Meeting.
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评估全氟和多氟烷基物质（PFASs）暴露的环境危害和风险：SETAC重点主题会议的成果。
DOI：
10.1002/etc.4784
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发表时间：
2021-03
影响因子：
4.1
通讯作者：
Fenton SE
中科院分区：
文献类型：
--
作者：
Johnson MS;Buck RC;Cousins IT;Weis CP;Fenton SE
全氟烷基和多氟烷基物质（PFAS）是一组高度氟化的合成化学品，最初开发用于表面活性剂和表面保护剂。越来越多地在环境介质中发现这类特定物质（例如，地表水、土壤、沉积物、食物来源），以及公众、立法者和普通民众对接触人类和环境受体的担忧。数据表明，一些PFAS（如某些长链PFAS）具有生物蓄积性，并且具有较长的生物半衰期，特别是在人类中。各种生物体的毒性数据各不相同，其毒代动力学也各不相同。2019年8月12日至15日，在北卡罗来纳州的达勒姆（美国）召开了环境毒理学和化学学会（SETAC）重点主题会议和研讨会，主题为PFAS的环境风险评估，汇集了来自地球仪的专家，重点介绍了与评估暴露的环境和人类健康风险相关的研究的最新进展。重点专题会议和研讨会的目标是：1）审查有关全氟辛烷磺酸化学分类和分组、环境化学、检测技术、归宿和迁移、接触潜力、人类健康毒性和生态毒性的新的和正在出现的信息;和2）利用与会者的专业知识，讨论并制定路线图，以优先考虑特定PFAS的研究，一种评估方法，考虑了用于外推接触的机械（包括计算）数据以及环境接触途径中不同物种/情景和化合物的数据。我们提出了讨论的关键问题。环境毒理学化学2021;40：543-549。联系我们_SETAC
Per‐ and polyfluoroalkyl substances (PFAS) are a group of highly fluorinated synthetic chemicals that were originally developed for uses as surfactants and surface protectors. Increasingly, specific substances of this class are being found in environmental media (e.g., surface water, soils, sediments, food sources), and concerns regarding exposure to humans and environmental receptors have been described by the public, legislators, and the general population. Data suggest that some PFAS (such as certain of the long‐chain ones) bioaccumulate and have long biological half‐lives, particularly in humans. Toxicity data in various organisms are variable as are their toxicokinetics. A Society of Environmental Toxicology and Chemistry (SETAC) Focused Topic Meeting and workshop entitled Environmental Risk Assessment of PFAS convened during 12 to 15 August, 2019 in Durham, North Carolina (USA) and brought together experts from around the globe to highlight recent advances in research pertinent to evaluating environmental and human health risks from exposures. The objectives of the Focused Topic Meeting and workshop were: 1) to review new and emerging information on PFAS chemical classification and grouping, environmental chemistry, detection technology, fate and transport, exposure potential, human health toxicity, and ecological toxicity; and 2) to harness the expertise of attendees to discuss and formulate a roadmap to prioritize the study of specific PFAS with the goal of developing a risk assessment approach that considers mechanistic (including computational) data for extrapolating exposure and data across different species/scenarios and compounds within environmental exposure pathways. We present the key issues that were discussed.Environ Toxicol Chem2021;40:543–549. © 2020 SETAC
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