Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial.
Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial.
复制标题
DOI：
10.3389/fimmu.2018.00591
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
Yaqoob P
中科院分区：
文献类型：
--
作者：
Przemska-Kosicka A;Childs CE;Maidens C;Dong H;Todd S;Gosney MA;Tuohy KM;Yaqoob P
自然杀伤（NK）细胞是流感感染免疫反应的重要组成部分，但在衰老过程中会发生改变，这可能在老年人对感染和疫苗接种的反应受损中发挥作用。因此，NK细胞活性的增强可以提供一种方法来改善老年受试者对疫苗接种的免疫反应，预益生菌和益生菌提供了通过改变肠道微生物群来调节抗病毒防御的机会。本研究探讨了一种新型益生菌——长双歧杆菌的作用。在一项双盲、随机对照试验中，婴儿CCUG 52486与益生元低聚葡萄糖（B. longum + Gl-OS）联合对年轻人和老年人季节性流感疫苗接种的NK细胞反应。衰老对NK细胞表型有显著影响，其中最显著的是CD56dim细胞增加，主要反映在CD16+亚群中，CD56bright细胞减少，主要反映在CD16−亚群中，免疫衰老标志物CD57在NK细胞亚群中的表达增加。然而，这些变化仅部分转化为NK细胞活性的差异，当以每个细胞为基础分析时，观察到老年受试者中NK细胞活性降低的趋势。在年轻人中，接种流感疫苗增加了cd56亮细胞的比例，降低了cd56暗细胞的比例，但在老年受试者中没有。尽管接种疫苗后NK细胞活性在年轻人和老年人之间没有显著差异，但只有老年人接种后NK细胞活性低与血清转化差有关。在流感疫苗接种前后，合成菌对NK细胞表型和活性均无影响。总之，衰老与NK细胞群表型的显著改变有关，有证据表明，老年受试者对流感疫苗的NK细胞反应受损。衰老对NK细胞表型和活性的影响不能被长芽孢杆菌+ Gl-OS所抵消。，标识符NCT01066377。
Natural killer (NK) cells are an important component of the immune response to influenza infection, but are subject to alteration during aging, which may play a role in impaired response to infection and vaccination in older people. Enhancement of NK cell activity could, therefore, present a means to improve the immune response to vaccination in older subjects, and pre- and probiotics offer an opportunity to modulate antiviral defenses via alteration of the gut microbiota. This study investigated the effect of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486, combined with a prebiotic, gluco-oligosaccharide (B. longum + Gl-OS), on the NK cell response to seasonal influenza vaccination in young and older subjects in a double-blind, randomized controlled trial. There were significant effects of aging on NK cell phenotype, the most notable of which were an increase in CD56dim cells, mainly reflected in the CD16+ subset, a decrease in CD56bright cells, mainly reflected in the CD16− subset, and greater expression of the immunosenescence marker, CD57, on NK cell subsets. However, these changes only partially translated to differences in NK cell activity, observed as trends toward reduced NK cell activity in older subjects when analyzed on a per cell basis. Influenza vaccination increased the proportion of CD56bright cells and decreased the proportion of CD56dim cells, in young, but not older subjects. Although NK cell activity in response to vaccination was not significantly different between the young and older subjects, low post-vaccination NK cell activity was associated with poor seroconversion in only the older subjects. There was no influence of the synbiotic on NK cell phenotype or activity, either before or after influenza vaccination. In conclusion, aging is associated with marked alteration of the phenotype of the NK cell population and there was evidence of an impaired NK cell response to influenza vaccination in older subjects. The effects of aging on NK cell phenotype and activity could not be offset by B. longum + Gl-OS. , identifier NCT01066377.
登录
查看更多内容
DOI：
10.4049/jimmunol.0903357
发表时间：
2010-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hall LJ;Clare S;Dougan G
通讯作者：
Dougan G
影响因子：
3.7
作者：
Jost S;Quillay H;Reardon J;Peterson E;Simmons RP;Parry BA;Bryant NN;Binder WD;Altfeld M
通讯作者：
Altfeld M
影响因子：
5.4
作者：
Du, Ning;Zhou, Jianfang;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
3.9
作者：
Borrego, F;Alonso, MC;Solana, R
通讯作者：
Solana, R
影响因子：
6.3
作者：
de Vrese, M;Winkler, P;Schrezenmeir, J
通讯作者：
Schrezenmeir, J