Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity.
Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity.
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DOI：
10.1007/s42000-020-00265-z
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Cummings BP
中科院分区：
文献类型：
--
作者：
Allegretti JR;Kassam Z;Hurtado J;Marchesi JR;Mullish BH;Chiang A;Thompson CC;Cummings BP
粪便微生物移植(FMT)已被用于治疗代谢综合征的研究，取得了不同程度的成功。然而，利用FMT预防代谢综合征的可能性迄今尚不清楚。对FMT在肥胖代谢健康患者中的双盲、随机、安慰剂对照先导试验进行了二次分析。测量餐后血糖和胰岛素水平。共有22名患者入选，每组11名。与安慰剂相比，FMT组的血糖或胰岛素曲线下面积(AUC)没有基线差异。与安慰剂组相比，12周时葡萄糖AUC有显著变化(葡萄糖AUC(mg/dl x 60min)：579vs1978，p=0.03)(胰岛素AUC(μU/mlx60min)变化：137vs2728，p=0.01)。这些数据表明，FMT可能在预防肥胖症患者发生代谢综合征方面具有潜在作用。
Fecal microbiota transplantation (FMT) has been studied for the treatment of metabolic syndrome with varying success. However, the possibility of utilizing FMT to prevent metabolic syndrome is to date unknown. Secondary analysis of a double-blind, randomized, placebo-controlled pilot trial of FMT in obese metabolically healthy patients was conducted. Post-prandial glucose and insulin levels were measured. A total of 22 patients were enrolled, 11 in each arm. There were no baseline differences in the area under the curve (AUC) of glucose or insulin in the FMT group compared to placebo. There was a significant change in glucose AUC at week 12 compared to baseline, and in the insulin AUC at week 6 compared to baseline in the FMT group vs. placebo (change in glucose AUC (mg/dl x 60min): 579 vs 1978, p=0.03) (change in insulin AUC (μU/ml x 60min): 137 vs 2728, p=0.01). These data suggest that FMT may have a potential role in preventing the development of metabolic syndrome in patients with obesity.
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