The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig.

The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig.
复制标题

上皮去除对猫和豚鼠离体中央气道中非肾上腺素能、非胆碱能抑制反应的影响。

DOI:
10.1016/0014-2999(88)90237-3
复制
发表时间:
1988
影响因子:
5
通讯作者:
Diamond,L
Diamond,L
中科院分区:
医学2区
文献类型:
--
作者:
Thompson,DC;Wells,JL;Altiere,RJ;Diamond,L

文献摘要

参考文献

被引文献

相似文献

从猫科动物或经吲哚美辛处理的豚鼠气管去除上皮对组织敏感性或对药理学激动剂或电场刺激的收缩作用的反应性没有影响。在猫的肺门支气管中,上皮去除对组织对乙酰胆碱或电场刺激的敏感性或反应性没有影响,但增加了支气管对血清素的敏感性,而不影响反应性。两种物种的气道制剂中电场刺激引起的非肾上腺素非胆碱能(NANC)松弛反应不受上皮去除的影响。这些结果表明上皮不调节猫气管中的收缩反应,但可能调节猫肺门支气管中特定收缩激动剂的作用。此外,NANC 松弛反应似乎独立于气道上皮发生。
Epithelium removal from the feline or the indomethacin-treated guinea pig trachea had no effect on tissue sensitivity or responsiveness to the contractile actions of pharmacological agonists or electrical field stimulation. In the feline hilar bronchus, epithelium removal had no effect on tissue sensitivity or responsiveness to acetylcholine or electrical field stimulation but increased bronchial sensitivity to serotonin without affecting responsiveness. Non-adrenergic non-cholinergic (NANC) relaxation responses elicited by electrical field stimulation in airway preparations from either species were unaffected by epithelium removal. These results suggest that the epithelium does not modulate contractile responses in the feline trachea but may modulate the actions of specific contractile agonists in the feline hilar bronchus. Further, NANC relaxation responses appear to occur independently of the airway epithelium.
上皮去除后花生四烯酸诱导的豚鼠气管松弛逆转为收缩。
DOI: 10.1016/0014-2999(86)90591-1
发表时间: 1986
影响因子: 5
作者:
F. Nijkamp;G. Folkerts
通讯作者: G. Folkerts
DOI: 10.1111/j.1476-5381.1986.tb10192.x
发表时间: 1986-03-01
影响因子: 7.3
作者:
HOLROYDE, MC
通讯作者: HOLROYDE, MC
呼吸道上皮抑制支气管平滑肌张力。
DOI: 10.1152/jappl.1985.58.3.834
发表时间: 1985
期刊: Journal of applied physiology (Bethesda, Md. : 1985)
影响因子: --
作者:
Flavahan,NA;Aarhus,LL;Rimele,TJ;Vanhoutte,PM
通讯作者: Vanhoutte,PM
豚鼠气管肌中非肾上腺素能抑制神经的证据。
DOI: 10.1152/ajplegacy.1973.224.5.1072
发表时间: 1973
期刊: The American journal of physiology
影响因子: --
作者:
R. Coburn;T. Tomita
通讯作者: T. Tomita
气管上皮释放血管平滑肌松弛因子:生物测定证明。
DOI: 10.1016/0014-2999(86)90586-8
发表时间: 1986
影响因子: 5
作者:
M. Ilhan;I. Sahin
通讯作者: I. Sahin