The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig.
The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig.
复制标题
上皮去除对猫和豚鼠离体中央气道中非肾上腺素能、非胆碱能抑制反应的影响。
DOI:
10.1016/0014-2999(88)90237-3
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发表时间:
1988
影响因子:
5
通讯作者:
Diamond,L
中科院分区:
文献类型:
--
作者:
Thompson,DC;Wells,JL;Altiere,RJ;Diamond,L
Epithelium removal from the feline or the indomethacin-treated guinea pig trachea had no effect on tissue sensitivity or responsiveness to the contractile actions of pharmacological agonists or electrical field stimulation. In the feline hilar bronchus, epithelium removal had no effect on tissue sensitivity or responsiveness to acetylcholine or electrical field stimulation but increased bronchial sensitivity to serotonin without affecting responsiveness. Non-adrenergic non-cholinergic (NANC) relaxation responses elicited by electrical field stimulation in airway preparations from either species were unaffected by epithelium removal. These results suggest that the epithelium does not modulate contractile responses in the feline trachea but may modulate the actions of specific contractile agonists in the feline hilar bronchus. Further, NANC relaxation responses appear to occur independently of the airway epithelium.
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影响因子:
5
作者:
F. Nijkamp;G. Folkerts
通讯作者:
G. Folkerts
影响因子:
7.3
作者:
HOLROYDE, MC
通讯作者:
HOLROYDE, MC
DOI:
10.1152/jappl.1985.58.3.834
发表时间:
1985
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Flavahan,NA;Aarhus,LL;Rimele,TJ;Vanhoutte,PM
通讯作者:
Vanhoutte,PM
DOI:
10.1152/ajplegacy.1973.224.5.1072
发表时间:
1973
期刊:
The American journal of physiology
影响因子:
--
作者:
R. Coburn;T. Tomita
通讯作者:
T. Tomita
影响因子:
5
作者:
M. Ilhan;I. Sahin
通讯作者:
I. Sahin