Measurement of the absolute optical properties and cerebral blood volume of the adult human head with hybrid differential and spatially resolved spectroscopy
Measurement of the absolute optical properties and cerebral blood volume of the adult human head with hybrid differential and spatially resolved spectroscopy
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利用混合微分和空间分辨光谱测量成人头部的绝对光学特性和脑血量
DOI：
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发表时间：
2006
影响因子：
3.5
通讯作者：
C. Elwell
中科院分区：
文献类型：
--
作者：
T. Leung;I. Tachtsidis;Martin Smith;D. Delpy;C. Elwell
建立了一种混合差分和空间分辨光谱（SRS）技术，用于测量成人头部的绝对吸收系数（μ A）、减少散射系数（μ s）和脑血容量（CBV）。具有微分和SRS功能的光谱仪已用于对12个受试者进行测量。使用混合技术考虑了两种版本的计算，一种考虑了水作为发色团以及氧和脱氧血红蛋白，另一种忽略了水。CBV也使用先前描述的技术测量，该技术基于改变动脉饱和度（SaO2），由脉搏血氧计单独测量，结果平均±SD CBVa（个体内变异系数）= 2.22±1.06 ml/100 g（29.9%）。（CBV的上标表示不同的计算基础。）采用忽略水的杂交技术，CBV0 = 3.18±0.73 ml/100 g (10.0%), μ0a(813 nm) = 0.010±0.003 mm - 1, μ s(813 nm) = 1.19±0.55 mm - 1（数据引用于813 nm）。考虑水时，CBVw = 3.05±0.77 ml/100 g (10.5%), μwa(813 nm) = 0.010±0.003 mm−1,μ ws(813 nm) = 1.28±0.56 mm−1。CBV0/CBVw、CBV0/CBVa和CBVw/CBVa的平均偏差分别为0.14±0.09、0.79±1.22和0.65±1.24 ml/100 g。μ0a(813 nm)/μwa（813 nm）和μ ' 0s(813 nm)/μ ' ws（813 nm）的平均偏差分别为（5.9±10.0）× 10−4 mm−1和- 0.084±0.266 mm−1。我们描述的方法扩展了当前SRS仪器的功能。
A hybrid differential and spatially resolved spectroscopy (SRS) technique has been developed to measure absolute absorption coefficient (μa), reduced scattering coefficient (μ′s) and cerebral blood volume (CBV) in the adult human head. A spectrometer with both differential and SRS capabilities has been used to carry out measurements in 12 subjects. Two versions of the calculation have been considered using the hybrid technique, with one considering water as a chromophore as well as oxy- and deoxy-haemoglobin, and one ignoring water. The CBV has also been measured using a previously described technique based on changing the arterial saturation (SaO2) measured separately by a pulse oximeter, resulting in mean ± SD CBVa (intra-individual coefficient of variation) = 2.22 ± 1.06 ml/100 g (29.9%). (The superscript on CBV indicates the different calculation basis.) Using the hybrid technique with water ignored, CBV0 = 3.18 ± 0.73 ml/100 g (10.0%), μ0a(813 nm) = 0.010 ± 0.003 mm−1 and μ′0s(813 nm) = 1.19 ± 0.55 mm−1 (data quoted at 813 nm). With water considered, CBVw = 3.05 ± 0.77 ml/100 g (10.5%), μwa(813 nm) = 0.010 ± 0.003 mm−1 and μ′ws(813 nm) = 1.28 ± 0.56 mm−1. The mean biases between CBV0/CBVw, CBV0/CBVa and CBVw/CBVa are 0.14 ± 0.09, 0.79 ± 1.22 and 0.65 ± 1.24 ml/100 g. The mean biases between μ0a(813 nm)/μwa(813 nm) and μ′0s(813 nm)/μ′ws(813 nm) are (5.9 ± 10.0) × 10−4 mm−1 and −0.084 ± 0.266 mm−1, respectively. The method we describe extends the functionality of the current SRS instrumentation.
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影响因子：
1.9
作者：
Srinivasan, S;Pogue, BW;Paulsen, KD
通讯作者：
Paulsen, KD
影响因子：
4.8
作者：
Cerussi, AE;Berger, AJ;Tromberg, BJ
通讯作者：
Tromberg, BJ
用于确定组织氧合的时间和频率分辨光谱的定量。
影响因子：
2.9
作者：
Sevick,EM;Chance,B;Leigh,J;Nioka,S;Maris,M
通讯作者：
Maris,M
正常衰老过程中振动引起的局部脑血流反应。
DOI：
10.1038/jcbfm.1992.79
发表时间：
1992
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Tempel,LW;Perlmutter,JS
通讯作者：
Perlmutter,JS
DOI：
10.1098/rstb.1997.0055
发表时间：
1997-06-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Gratton, E;Fantini, S;Fabiani, M
通讯作者：
Fabiani, M