Vibration-induced regional cerebral blood flow responses in normal aging.
Vibration-induced regional cerebral blood flow responses in normal aging.
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正常衰老过程中振动引起的局部脑血流反应。
DOI：
10.1038/jcbfm.1992.79
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Perlmutter,JS
中科院分区：
文献类型：
--
作者：
Tempel,LW;Perlmutter,JS
正电子发射断层扫描(PET)可以测量任务诱发的局部脑血流量(RCBF)变化，为绘制脑功能图提供了强有力的工具。许多使用这些技术的研究都调查了健康的年轻受试者的反应。由于许多病理情况在老年受试者中更为常见，因此有必要将这些患者的血流反应与适当年龄匹配的对照组进行比较。此外，正常衰老对这种血流反应的影响尚不清楚。出于这两个原因，我们设计了这项研究，以确定在正常人中，振动诱导的CBF反应是否随着年龄的增长而变化。对26例20~72岁的受试者(平均39例，SD=19例)进行了正电子发射计算机断层扫描(PET)和双氧水灌注法测定脑血流量。区域反应通过减影图像分析来识别。左右手振动在对侧主感觉运动区(PSA)和辅助运动区(SMA)产生一致的反应。通过线性回归将反应幅度与年龄进行比较。PSA或SMA患者的年龄与振动反应无明显关系(PSAR=−0.28，p=0.054；SMAR=−0.33，p=0.13)。功率分析显示出高度的置信度(PSA为99.7%，SMA为87%)，至少可以检测到反应幅度与年龄之间的中等相关性(r=0.6)。我们的结论是，rCBF对手振动触觉刺激的反应不会随着正常年龄的增加而改变。
Task-induced changes in regional CBF (rCBF) can be measured with positron emission tomography (PET) and provide a powerful tool to map brain function. Many studies using these techniques have investigated responses in healthy young subjects. Since many pathological conditions occur more commonly in older subjects, it is necessary to compare blood flow responses in these patients with appropriately age-matched controls. Furthermore, the effects of normal aging on such blood flow responses remain unknown. For both reasons, we designed this study to determine whether vibration-induced CBF responses change with advancing age in normals. CBF was measured with PET and bolus-administered H215O in 26 subjects from 20 to 72 years old (mean = 39; SD = 19). Regional responses were identified by subtraction-image analysis. Left and right hand vibration produced consistent responses in contralateral primary sensorimotor area (PSA) and supplementary motor area (SMA). Response magnitudes were compared to age by linear regression. There were no substantial relationships between age and responses to vibration for PSA or SMA (PSAr= −0.28,p= 0.054; SMAr= −0.33,p= 0.13). Power analysis demonstrates a high degree of confidence (99.7% for PSA and 87% for SMA) for detecting at least a moderate correlation (r= 0.6) between response magnitude and age. We conclude that the rCBF responses to vibrotactile hand stimulation do not change with normal aging.
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DOI：
--
发表时间：
1979-04
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Phelps;S. C. Huang;E. Hoffman;D. Kuhl
通讯作者：
M. Phelps;S. C. Huang;E. Hoffman;D. Kuhl
人体局部脑血容量对二氧化碳的反应
影响因子：
20.1
作者：
J. Greenberg;A. Alavi;M. Reivich;D. Kuhl;B. Uzzell
通讯作者：
B. Uzzell
外周静脉血细胞比容与脑血细胞比容的关系。
影响因子：
3.3
作者：
V. Levin;J. Ausman
通讯作者：
J. Ausman
动脉CO 2 张力对脑血流量、平均通过时间和血管容量的影响。
影响因子：
3.3
作者：
A. Smith;G. Neufeld;A. Ominsky;H. Wollman
通讯作者：
H. Wollman
影响因子：
11.2
作者：
R. Grubb;M. Raichle;C. S. Higgins;J. Eichling
通讯作者：
J. Eichling