Beta endorphin in serum and follicular fluid of PCOS- and non-PCOS women.
Beta endorphin in serum and follicular fluid of PCOS- and non-PCOS women.
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DOI：
10.1007/s00404-018-4793-6
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发表时间：
2018-07
影响因子：
2.6
通讯作者：
Seeber B
中科院分区：
文献类型：
--
作者：
Jaschke N;Lunger F;Wildt L;Seeber B
比较PCOS和非PCOS妇女血清和卵泡液（FF）中β内啡肽的浓度。其次，研究β内啡肽与其他参数之间的关系。59名接受体外受精（IVF）的妇女被纳入研究。根据鹿特丹标准将16例患者分为PCOS组。其余43名女性作为对照。取卵期间采集卵泡液，并在同一天采集外周血样本。测定血清和卵泡液中β内啡肽浓度，血清胰岛素、葡萄糖、LH、雌二醇和孕酮水平。此外，在开始刺激方案之前测量睾酮。PCOS和非PCOS妇女之间的β内啡肽水平没有差异。血清中肽的浓度高于FF，可能是由于诱导排卵后收集FF，对应于早期黄体期。我们发现了一个显着的相关性之间的数量成熟中期II（MII）卵母细胞检索和β内啡肽浓度FF。在患有生化高雄激素血症的女性中，FF中的β内啡肽水平与睾酮水平相关。接受IVF的PCOS和非PCOS妇女的血清和FF中β内啡肽浓度没有差异。然而，与性激素一起，β内啡肽可能在卵母细胞成熟中起关键作用。
To compare the concentrations of beta endorphin in serum and follicular fluid (FF) of PCOS- and non-PCOS women. Secondarily, to investigate associations between beta endorphin and other parameters. Fifty-nine women undergoing in vitro fertilization (IVF) were included in the study. Sixteen were stratified to the PCOS group using the Rotterdam criteria. The remaining 43 women served as controls. Follicular fluid was collected during oocyte retrieval and peripheral blood sampling was performed on the same day. Beta endorphin concentrations in serum and follicular fluid, serum levels of insulin, glucose, LH, estradiol and progesterone were measured. Additionally, testosterone was measured before starting the stimulation protocol. There was no difference in beta endorphin levels between PCOS- and non-PCOS women. The concentration of the peptide was higher in serum than in FF, likely due to collection of FF after ovulation induction and corresponding to the early luteal phase. We found a significant correlation between the number of mature Metaphase II (MII) oocytes retrieved and beta endorphin concentration in FF. In women with biochemical hyperandrogenemia, beta endorphin levels in FF correlated with testosterone levels. Beta Endorphin concentrations in serum and FF do not differ between PCOS- and non PCOS-women undergoing IVF. However, together with sex hormones, beta endorphin might play a key role in oocyte maturation.
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DOI：
10.1262/jrd.2014-161
发表时间：
2015
期刊：
The Journal of reproduction and development
影响因子：
--
作者：
Makita M;Miyano T
通讯作者：
Miyano T
影响因子：
4
作者：
Agirregoitia, Ekaitz;Peralta, Laura;Agirregoitia, Naiara
通讯作者：
Agirregoitia, Naiara
影响因子：
3.2
作者：
CUMMING, DC;REID, RL;YEN, SSC
通讯作者：
YEN, SSC
影响因子：
3.8
作者：
Faletti, AG;Mohn, C;Rettori, V
通讯作者：
Rettori, V
影响因子：
4.8
作者：
MELNER, MH;YOUNG, SL;KOOS, RD
通讯作者：
KOOS, RD