Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.
Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.
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DOI：
10.1016/j.ogla.2021.10.005
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发表时间：
2022-05
影响因子：
2.9
通讯作者：
Saeedi, Osamah J.
中科院分区：
文献类型：
--
作者：
Vinnett, Alfred;Kandukuri, Jayanth;Le, Christopher;Cho, Kyoung-A;Sinha, Avigyan;Asanad, Samuel;Thompson, Ginger;Chen, Victoria;Rege, Abhishek;Saeedi, Osamah J.
评估使用最近FDA批准的激光散斑衬度成像设备XyCAM RI获得的血流速度指数（BFVi）指标的可重复性，并表征对照、疑似青光眼和青光眼受试者之间这些指标的差异。前瞻性观察性研究46例受试者对照组20例，可疑青光眼组16例，青光眼组10例;每个受试者一只眼睛）在视神经盘，视神经盘血管，在同一天的四个成像会话中的视盘灌注区域和黄斑。使用每个感兴趣区域（ROI）中每个指标的变异系数（CV）计算会话内和会话间变异性。使用双变量和多变量分析比较青光眼受试者、青光眼可疑者和对照者之间的每个动态BFVi变量的值。Pearson相关系数用于将每个ROI中的每个变量与年龄、眼内压、杯盘比、平均差、模式标准差、视网膜神经纤维层厚度和最小边缘宽度相关联。每个ROI中每个动态BFVi指标的会话内和会话间变异性的CV，以及每个诊断组之间每个ROI中每个指标的差异。平均值、峰值、谷值以及VRI、VFI、TtR和TtF的会话间CV范围为3.2 ± 2.5%至11.0 ± 3.8%。年龄、杯盘比、光学相干断层扫描指标和视野指标与动态BFVi变量显著相关。除中央凹外，青光眼患者的峰值、平均值、下降值、VRI和VFI均显著低于对照组。这些指标在青光眼患者中也明显低于椎间盘血管中的可疑患者。用XyCAM RI测量的动态血流指标是可靠的，与结构性和功能性青光眼指标相关，并且在青光眼受试者、青光眼可疑者和对照者之间存在显著差异。XyCAM RI可作为未来青光眼管理的重要工具。一种新的激光散斑对比成像装置可重复测量视神经头和黄斑的动态眼血流。青光眼患者的动态血流指标低于可疑者和对照者。
To assess the repeatability of blood flow velocity index (BFVi) metrics obtained with a recently FDA-cleared laser speckle contrast imaging device, the XyCAM RI, and characterize differences in these metrics between control, glaucoma suspect, and glaucoma subjects. Prospective observational study 46 subjects (20 control, 16 glaucoma suspect, and 10 glaucoma; one eye per subject) Key dynamic BFVi metrics–mean, peak, dip, volumetric rise index (VRI), volumetric fall index (VFI), time to rise (TtR), time to fall (TtF), blow out time (BOT), skew, acceleration time index (ATI)–were measured in the optic disc, optic disc vessels, optic disc perfusion region, and macula in four imaging sessions on the same day. Intrasession and intersession variability were calculated using the coefficient of variation (CV) for each metric in each region of interest (ROI). Values for each dynamic BFVi variable were compared between glaucoma subjects, glaucoma suspects, and controls using bivariate and multivariable analysis. Pearson correlation coefficients were used to correlate each variable in each ROI with age, intraocular pressure, cup to disc ratio, mean deviation, pattern standard deviation, retinal nerve fiber layer thickness, and minimum rim width. CV for the intrasession and intersession variability for each dynamic BFVi metric in each ROI, and differences in each metric in each ROI between each diagnostic group. The intersession CV for mean, peak, dip, as well as VRI, VFI, TtR, and TtF ranged from 3.2 ± 2.5% to 11.0 ± 3.8%. Age, cup-to-disc ratio, optical coherence tomography metrics, and visual field metrics showed significant correlations with dynamic BFVi variables. Peak, mean, dip, VRI, and VFI, were significantly lower in glaucoma subjects than in control subjects in all ROI except the fovea. These metrics were also significantly lower in glaucoma subjects than suspects in the disc vessels. Dynamic blood flow metrics measured with the XyCAM RI are reliable, associated with structural and functional glaucoma metrics, and significantly different between glaucoma subjects, glaucoma suspects, and controls. The XyCAM RI may serve as an important tool in glaucoma management in the future. A novel laser speckle contrast imaging device reproducibly measures dynamic ocular blood flow in the optic nerve head and macula. Dynamic blood flow metrics were lower in glaucoma subjects as compared to suspects and controls.
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影响因子：
13.7
作者：
Pazos, Marta;Anna Dyrda, Agnieszka;Anton, Alfonso
通讯作者：
Anton, Alfonso
DOI：
10.2147/opth.s22093
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
通讯作者：
Nakazawa T
DOI：
10.1136/bjophthalmol-2013-304393
发表时间：
2014-11
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Kanakamedala P;Harris A;Siesky B;Tyring A;Muchnik M;Eckert G;Abrams Tobe L
通讯作者：
Abrams Tobe L
影响因子：
4.4
作者：
Nagahara, Miyuki;Tamaki, Yasuhiro;Araie, Makoto
通讯作者：
Araie, Makoto
影响因子：
2
作者：
Burgansky-Eliash, Zvia;Bartov, Elisha;Gaton, Dan
通讯作者：
Gaton, Dan