MicroRNAs in kidney development: lessons from the frog.
MicroRNAs in kidney development: lessons from the frog.
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DOI：
10.4161/rna.7.3.11692
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发表时间：
2010-05
期刊：
影响因子：
4.1
通讯作者：
Tran U
中科院分区：
文献类型：
--
作者：
Wessely O;Agrawal R;Tran U
肾脏发育是多种细胞类型如何通过各种诱导事件整合成高度特化的上皮结构的范例。转录因子和信号通路网络已被确定为关键的调节因子。最近发现的一组小型非编码 RNA，即 microRNA (miRNA)，又增加了一层新的复杂性。使用爪蟾前肾和小鼠后肾的研究表明，miRNA 对 mRNA 稳定性和翻译效率的严格调节也非常重要。 miRNA 和转录网络之间的相互作用为系统提供了可塑性和鲁棒性。重要的是，miRNA 不仅是肾脏发育早期所必需的，而且在生命后期也是必需的。因此，它们可以提供一种在稳态和损伤期间维持/调节肾功能的方法。
Kidney development is a paradigm of how multiple cell types are integrated into highly specialized epithelial structures via various inductive events. A network of transcription factors and signaling pathways have been identified as crucial regulators. The recent discovery of a group of small, non-coding RNAs, microRNAs (miRNAs), has added a new layer of complexity. Studies using the pronephric kidney of Xenopus and the metanephric kidney of mouse have demonstrated that a tight regulation of mRNA stability and translation efficiency by miRNAs is very important as well. The interplay between miRNAs and the transcriptional network provides plasticity and robustness to the system. Importantly, miRNAs are not only necessary for early aspects of kidney development, but also later in life. As such they may provide a mean to maintain/modulate kidney function during homeostasis and injury.
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