Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis.
Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis.
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DOI：
10.1038/s41467-021-22674-3
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发表时间：
2021-05-13
影响因子：
16.6
通讯作者：
Gu Z
中科院分区：
文献类型：
--
作者：
Li H;Wang Z;Chen Z;Ci T;Chen G;Wen D;Li R;Wang J;Meng H;Bryan Bell R;Gu Z;Dotti G;Gu Z
Although therapies of cancer are advancing, it remains challenging for therapeutics to reach the sites of metastasis, which accounts for majority of cancer associated death. In this study, we have developed a strategy that guides an anti-programmed cell death-ligand 1 (aPDL1) antibody to accumulate in metastatic lesions to promote anti-tumour immune responses. Briefly, we have developed a combination in which Vadimezan disrupts tumour blood vessels of tumour metastases and facilitates the recruitment and activation of adoptively transferred aPDL1-conjugated platelets. In situ activated platelets generate aPDL1-decorated platelet-derived microparticles (PMP) that diffuse within the tumour and elicit immune responses. The proposed combination increases 10-fold aPDL1 antibody accumulation in lung metastases as compared to the intravenous administration of the antibody and enhances the magnitude of immune responses leading to improved antitumour effects. Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.
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影响因子：
2.9
作者：
Svensson E;Christiansen CF;Ulrichsen SP;Rørth MR;Sørensen HT
通讯作者：
Sørensen HT
DOI：
10.1007/s10555-015-9586-9
发表时间：
2015-12
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
Fidler IJ;Kripke ML
通讯作者：
Kripke ML
DOI：
10.1016/b978-012369367-9/50782-5
发表时间：
2007-01-01
期刊：
PLATELETS, 2ND EDITION
影响因子：
--
作者：
Nieuwland, Rienk;Sturk, Augueste
通讯作者：
Sturk, Augueste
DOI：
10.1038/s41577-019-0269-6
发表时间：
2020-05
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Irvine DJ;Dane EL
通讯作者：
Dane EL
影响因子：
7.3
作者：
Elia AR;Caputo S;Bellone M
通讯作者：
Bellone M