A wearable patch for continuous analysis of thermoregulatory sweat at rest.
A wearable patch for continuous analysis of thermoregulatory sweat at rest.
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一种可穿戴贴片，用于持续分析休息时的体温调节汗液。
DOI：
10.1038/s41467-021-22109-z
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发表时间：
2021-03-23
影响因子：
16.6
通讯作者：
Javey A
中科院分区：
文献类型：
--
作者：
Nyein HYY;Bariya M;Tran B;Ahn CH;Brown BJ;Ji W;Davis N;Javey A
在久坐和日常活动中，身体会自然地、持续地分泌汗液来调节体温，其分泌速度可以反映潜在的健康状况，包括神经损伤、自主神经和代谢紊乱以及慢性压力。然而，低分泌率和蒸发为收集静息体温调节汗液进行无创身体生理分析带来了挑战。在这里，我们提出了可穿戴贴片，用于在休息时连续监测汗液，使用微流体来对抗蒸发，并能够选择性监测分泌速率。我们将亲水填料集成到传感通道中，以快速吸收汗水，减少实时测量所需的汗水积累时间。除了汗率传感器外，我们还集成了用于pH, Cl -和左旋多巴监测的电化学传感器。我们展示了与日常活动、应激事件、低血糖诱导出汗和帕金森病相关的动态汗液分析的贴片功能。通过使汗液分析与久坐、常规和日常活动兼容，这些贴片可以在休息时连续、自主地监测身体生理。低分泌率和蒸发为收集静息体温调节汗液进行无创身体生理分析带来了挑战。在这里，作者提出了可穿戴微流体贴片，用于休息时连续汗液监测，可以检测pH、Cl−和左旋多巴，用于与日常活动、应激事件、低血糖引起的出汗和帕金森病相关的动态汗液分析。
The body naturally and continuously secretes sweat for thermoregulation during sedentary and routine activities at rates that can reflect underlying health conditions, including nerve damage, autonomic and metabolic disorders, and chronic stress. However, low secretion rates and evaporation pose challenges for collecting resting thermoregulatory sweat for non-invasive analysis of body physiology. Here we present wearable patches for continuous sweat monitoring at rest, using microfluidics to combat evaporation and enable selective monitoring of secretion rate. We integrate hydrophilic fillers for rapid sweat uptake into the sensing channel, reducing required sweat accumulation time towards real-time measurement. Along with sweat rate sensors, we integrate electrochemical sensors for pH, Cl−, and levodopa monitoring. We demonstrate patch functionality for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson’s disease. By enabling sweat analysis compatible with sedentary, routine, and daily activities, these patches enable continuous, autonomous monitoring of body physiology at rest. Low secretion rates and evaporation pose challenges for collecting resting thermoregulatory sweat for non-invasive analysis of body physiology. Here the authors present wearable microfluidics-based patches for continuous sweat monitoring at rest that enable detection of pH, Cl−, and levodopa for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson’s disease.
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影响因子：
17.1
作者：
Koh A;Kang D;Xue Y;Lee S;Pielak RM;Kim J;Hwang T;Min S;Banks A;Bastien P;Manco MC;Wang L;Ammann KR;Jang KI;Won P;Han S;Ghaffari R;Paik U;Slepian MJ;Balooch G;Huang Y;Rogers JA
通讯作者：
Rogers JA
影响因子：
5
作者：
Allen AP;Kennedy PJ;Dockray S;Cryan JF;Dinan TG;Clarke G
通讯作者：
Clarke G
影响因子：
13.6
作者：
Lee H;Song C;Hong YS;Kim M;Cho HR;Kang T;Shin K;Choi SH;Hyeon T;Kim DH
通讯作者：
Kim DH
影响因子：
7.4
作者：
Jia, Wenzhao;Bandodkar, Amay J.;Wang, Joseph
通讯作者：
Wang, Joseph
影响因子：
2.4
作者：
Berger, Michael J.;Kimpinski, Kurt
通讯作者：
Kimpinski, Kurt