In Vitro Degradation of an Aromatic Polyanhydride with Enhanced Thermal Properties.
In Vitro Degradation of an Aromatic Polyanhydride with Enhanced Thermal Properties.
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DOI：
10.1016/j.polymdegradstab.2015.02.002
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发表时间：
2015-05-01
影响因子：
5.9
通讯作者：
Uhrich, Kathryn E.
中科院分区：
文献类型：
--
作者：
Snyder, Sabrina S.;Anastasiou, Theodore J.;Uhrich, Kathryn E.
聚酸酐由于其表面侵蚀行为导致零级释放而被研究作为药物递送载体。然而，许多聚酸酐具有热性质和溶解性性质，使得它们难以配制用于这些应用。聚[α，α′-双（邻羧基苯氧基）-对二甲苯]（oCPX）是一种芳香族聚酸酐，具有热性能和溶解性能，易于加工。聚合物的体外降解曲线显示出长达10天的诱导期，其中介质中的降解产物浓度最小，随后是生物相容性降解产物的稳定释放期。扫描电子显微镜图像和聚合物基质的分子量变化证实，这种聚合物主要是表面侵蚀。热性能，溶解性，聚合物降解时间和侵蚀机制的组合表明，聚（oCPX）是一个合适的候选基质延长，控制药物输送。
Polyanhydrides have been studied as a drug delivery vehicles due to their surface-eroding behavior which results in zero-order release. However, many polyanhyrides have thermal and solubility properties that make them difficult to formulate for these applications. Poly[α,α′-bis(ortho-carboxyphenoxy)-para-xylene] (oCPX) is an aromatic polyanhydride that has thermal and solubility properties enabling facile processing. The polymer's in vitro degradation profile exhibited an induction period up to 10 days in which degradation product concentration in the media was minimal, followed by a period of stable release of the biocompatible degradation product. Scanning electron microscope images and molecular weight changes of the polymer matrices confirm that this polymer is primarily surface-eroding. The combination of thermal properties, solubility, polymer degradation time, and erosion mechanism indicate that poly(oCPX) is be a suitable matrix candidate for extended, controlled drug delivery.
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影响因子：
4.9
作者：
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通讯作者：
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通讯作者：
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