Transcription factors involved in the regulation of natural killer cell development and function: an update.

Transcription factors involved in the regulation of natural killer cell development and function: an update.
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DOI:
10.3389/fimmu.2012.00319
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发表时间:
2012
影响因子:
7.3
通讯作者:
Saudemont A
Saudemont A
中科院分区:
医学2区
文献类型:
--
作者:
Luevano M;Madrigal A;Saudemont A

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自然杀伤(NK)细胞属于先天免疫系统,是对抗癌症和感染的免疫应答中的关键效应子。最近的研究有助于了解控制NK细胞命运的事件。基因敲除小鼠的使用使得能够发现NK细胞发育和功能所必需的关键转录因子(TF)。然而,解开这些TF的下游靶标及其对NK细胞的影响仍然是一个挑战。在这篇综述中,我们讨论了最新的TF被描述为参与调节NK细胞的发育和成熟。
Natural killer (NK) cells belong to the innate immune system and are key effectors in the immune response against cancer and infection. Recent studies have contributed to the knowledge of events controlling NK cell fate. The use of knockout mice has enabled the discovery of key transcription factors (TFs) essential for NK cell development and function. Yet, unwrapping the downstream targets of these TFs and their influence on NK cells remains a challenge. In this review, we discuss the latest TFs described to be involved in the regulation of NK cell development and maturation.
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