Capillary filtration‐absorption balance reconsidered in light of dynamic extravascular factors
Capillary filtration‐absorption balance reconsidered in light of dynamic extravascular factors
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根据动态血管外因素重新考虑毛细血管滤过吸收平衡
作者：
Levick
现在，关于血管外 Starling 压力的功能重要性的证据似乎是压倒性的，当考虑到这些术语时，很难坚持上游微血管过滤在很大程度上与持续的下游重吸收相匹配的传统概念。然而，在自发血管舒缩周期、交感神经引起的血管收缩期间和低血容量性低血压期间，可能会发生短暂吸收。持续吸收在特殊组织中是可能的，其中间质被独立的流“冲洗”（肠粘膜、肾皮质、淋巴结）。然而，理论和实验都表明，由于微血管对血浆蛋白的渗透性有限，大多数低压交换段的吸收无法维持，这导致毛细血管周围间质渗透压随着吸收微血管段的时间而升高。在毛细血管壁阻力较低的情况下，血管外液压阻力可能是净液体传输速率的进一步决定因素。
The evidence for the functional importance of extravascular Starling pressures now seems overwhelming, and when these terms are taken into account it is difficult to uphold the traditional conception that upstream microvascular filtration is largely matched by a sustained downstream reabsorption. Transient absorption can occur, however, during spontaneous vasomotion cycles, during sympathetic‐induced vasoconstriction and during hypovolaemic hypotension. Sustained absorption is possible in specialized tissues where the interstitium is ‘flushed’ by an independent stream (intestinal mucosa, renal cortex, lymph nodes). Both theory and experiment show, however, that absorption cannot be maintained across most low‐pressure exchange segments due to the finite permeability of microvessels to plasma protein, which leads to a rise in pericapillary interstitial oncotic pressure with time around absorbing microvascular segments. Extravascular hydraulic resistance may be a further determinant of net fluid transfer rate in situations where capillary wall resistance is low.
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影响因子：
--
作者：
Simkin,PA;Benedict,RS
通讯作者：
Benedict,RS
大鼠肠肌中单个毛细血管的液体交换。
DOI：
10.1152/ajpheart.1982.242.2.h268
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Gore,RW
通讯作者：
Gore,RW
盐水输注对血液组织白蛋白转运的影响。
DOI：
10.1152/ajpheart.1989.257.2.h525
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Renkin,EM;Rew,K;Wong,M;O'Loughlin,D;Sibley,L
通讯作者：
Sibley,L
影响因子：
--
作者：
RENKIN, EM
通讯作者：
RENKIN, EM