Sex differences feed into nuclear receptor signaling along the digestive tract.
Sex differences feed into nuclear receptor signaling along the digestive tract.
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DOI：
10.1016/j.bbadis.2021.166211
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发表时间：
2021-11-01
期刊：
影响因子：
--
通讯作者：
Anakk S
中科院分区：
文献类型：
--
作者：
Dean AE;Reichardt F;Anakk S
生理上的性别差异在临床和动物研究中都得到了注意。然而，男性和女性之间这些观察到的差异背后的机制仍然难以捉摸。核受体控制着广泛的生理通路，并在胃肠道中表达，包括口腔、胃、肝脏和肠道。我们研究了有关ER、AR、FXR和PPAR调节的文献，并强调了消化系统营养代谢的性别差异。我们根据它们的代谢功能和激素作用来选择这些核受体。有趣的是，我们注意到ER和FXR调节粘膜完整性和GLP-1分泌的靶基因重叠，而PPARα与ER和AR调节脂质代谢的靶基因重叠。性别差异不仅体现在核受体的基础表达上，还体现在其内源性配体浓度随养分有效性而波动的激活上。最后，在这篇综述中，我们推测核受体之间的相互作用可能以性别特异性的方式影响胃肠道的整体代谢决定。
Sex differences in physiology are noted in clinical and animal studies. However, mechanisms underlying these observed differences between males and females remain elusive. Nuclear receptors control a wide range of physiological pathways and are expressed in the gastrointestinal tract, including the mouth, stomach, liver and intestine. We investigated the literature pertaining to ER, AR, FXR, and PPAR regulation and highlight the sex differences in nutrient metabolism along the digestive system. We chose these nuclear receptors based on their metabolic functions, and hormonal actions. Intriguingly, we noted an overlap in target genes of ER and FXR that modulate mucosal integrity and GLP-1 secretion, whereas overlap in target genes of PPARα with ER and AR modulate lipid metabolism. Sex differences were seen not only in the basal expression of nuclear receptors, but also in activation as their endogenous ligand concentrations fluctuate depending on nutrient availability. Finally, in this review, we speculate that interactions between the nuclear receptors may influence overall metabolic decisions in the gastrointestinal tract in a sex-specific manner.
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DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
--
作者：
Abdel-Salam, OME;Czimmer, J;Mózsik, G
通讯作者：
Mózsik, G
DOI：
10.1002/hep.29305
发表时间：
2017-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Akinrotimi O;Riessen R;VanDuyne P;Park JE;Lee YK;Wong LJ;Zavacki AM;Schoonjans K;Anakk S
通讯作者：
Anakk S
影响因子：
5.1
作者：
Babickova, Janka;Tothova, L'ubomira;Celec, Peter
通讯作者：
Celec, Peter
影响因子：
13.5
作者：
BARBARA, L;SAMA, C;NARDIN, F
通讯作者：
NARDIN, F