Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese population: the Takahata study.
Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese population: the Takahata study.
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DOI：
10.7150/ijms.8919
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发表时间：
2014
影响因子：
3.6
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Sato K;Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Nunomiya K;Nakano H;Sato M;Kimura T;Nemoto T;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
背景：脂联素是一种抗炎和心脏保护的细胞因子。然而，一些研究表明，血浆脂联素水平与慢性阻塞性肺疾病患者的肺功能呈负相关，提示其具有促炎或肺破坏作用。脂联素是否是预测肺功能下降的有效生物标志物尚不清楚。本研究的目的是调查脂联素和肺功能之间的关系，在日本人谁参加了每年的健康检查。方法：2004年至2006年，对3,253名40岁或40岁以上的受试者进行肺活量测定和血液采样，包括血浆脂联素的测量，这些受试者参加了日本高田市以社区为基础的年度健康检查。2011年，重新进行肺功能测定，872例受试者（405例男性和467例女性）的数据可用于纵向分析。结果：血浆脂联素水平与年龄、体重指数（BMI）、丙氨酸氨基转移酶（ALT）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-c）水平显著相关。血浆脂联素水平被发现与终身吸烟（布林克曼指数，BI）仅在男性。男性和女性的血浆脂联素水平与每用力肺活量1秒用力呼气量（FEV 1）呈负相关。此外，在两种性别中，FEV 1的年度变化与血浆脂联素水平呈负相关。多元线性回归分析显示，这种关联独立于其他混杂因素，如年龄，BMI，BI，ALT，TG和HDL-c。结论：本研究的结果表明，脂联素水平是预测在一般人群中FEV 1下降。
Background:Adiponectin is an anti-inflammatory and cardio-protective cytokine. However, several studies have demonstrated that plasma adiponectin levels were inversely associated with pulmonary function in patients with chronic obstructive pulmonary disease, suggesting a proinflammatory or pulmonary-destructive role. It is still unclear whether adiponectin is a potent biomarker predicting declines in pulmonary function. The aim of this study was to investigate the association between adiponectin and pulmonary function among Japanese individuals who participated in an annual health check-up. Methods:Spirometry and blood sampling, including measurements of plasma adiponectin, were performed for 3,253 subjects aged 40 years or older who participated in a community-based annual health check-up in Takahata, Japan from 2004 to 2006. In 2011, spirometry was re-performed, and the data from 872 subjects (405 men and 467 women) were available for a longitudinal analysis. Results:Plasma adiponectin levels were found to be significantly associated with age, body mass index (BMI), and alanine aminotransferase (ALT), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-c) levels among both men and women in the study population. Plasma adiponectin levels were found to be associated with lifetime cigarette consumption (Brinkman index, BI) in men only. Plasma adiponectin levels were inversely correlated with forced expiratory volume in 1 s (FEV1) per forced vital capacity in both men and women. In addition, the annual change in FEV1 was inversely associated with plasma adiponectin levels in both genders. A multiple linear regression analysis revealed that this association was independent of other confounding factors such as age, BMI, BI, ALT, TG, and HDL-c. Conclusions:The results of the present study suggest that adiponectin levels are predictive of declines in FEV1 in the general population.
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影响因子：
3.7
作者：
Shibata Y;Inoue S;Igarashi A;Yamauchi K;Abe S;Aida Y;Nunomiya K;Sato M;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
影响因子：
3.6
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
通讯作者：
Kubota I
影响因子：
2
作者：
Aprahamian TR;Sam F
通讯作者：
Sam F
影响因子：
3.6
作者：
Sato M;Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
影响因子：
6
作者：
Chedid, Pia;Hurtado-Nedelec, Margarita;Marie, Jean-Claude
通讯作者：
Marie, Jean-Claude