Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies.
Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies.
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DOI：
10.3389/fimmu.2021.801797
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发表时间：
2021
影响因子：
7.3
通讯作者：
Seppo AE
中科院分区：
文献类型：
--
作者：
Pace RM;Williams JE;Järvinen KM;Meehan CL;Martin MA;Ley SH;Barbosa-Leiker C;Andres A;Yeruva L;Belfort MB;Caffé B;Navarrete AD;Lackey KA;Pace CDW;Gogel AC;Fehrenkamp BD;Klein M;Young BE;Rosen-Carole C;Diaz N;Gaw SL;Flaherman V;McGuire MA;McGuire MK;Seppo AE
关于母亲感染严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）期间和之后母乳和/或母乳喂养的风险和益处平衡的数据有限。研究在母体冠状病毒病2019（COVID-19）诊断后是否可以在乳汁和乳房中检测到SARS-CoV-2;并在症状发作或阳性诊断试验后2个月内表征对SARS-CoV-2刺突糖蛋白受体结合域（RBD）具有特异性的乳汁免疫球蛋白（IG）A的浓度。采用纵向研究设计，我们在2个月内从64名患有COVID-19的哺乳期妇女中收集了1至7次乳汁和乳房皮肤拭子，最早从诊断周开始。对牛奶和乳房拭子进行了SARS-CoV-2 RNA分析，并对牛奶进行了抗RBD伊加测试。SARS-CoV-2在任何牛奶样本或71%的乳腺拭子中都没有检测到。在29份（93%）洗乳后采集的乳房拭子中，有27份（93%）检测为SARS-CoV-2阴性。在乳房上检测到SARS-CoV-2与母亲咳嗽和其他家庭COVID-19有关。大多数（75%; 95%CI，70-79%; n=316）牛奶样本含有抗RBD伊加，并且在出现COVID-19症状或阳性检测后的前两周内浓度升高（P= 0.02）。77%的女性乳汁中的抗RBD伊加持续至少两个月。患有COVID-19的女性所产的牛奶不含SARS-CoV-2，可能是通过抗RBD伊加产生被动免疫的持久来源。这些结果支持鼓励哺乳期妇女在COVID-19期间和之后继续母乳喂养的建议。
Limited data are available regarding the balance of risks and benefits from human milk and/or breastfeeding during and following maternal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To investigate whether SARS-CoV-2 can be detected in milk and on the breast after maternal coronavirus disease 2019 (COVID-19) diagnosis; and characterize concentrations of milk immunoglobulin (Ig) A specific to the SARS-CoV-2 spike glycoprotein receptor binding domain (RBD) during the 2 months after onset of symptoms or positive diagnostic test. Using a longitudinal study design, we collected milk and breast skin swabs one to seven times from 64 lactating women with COVID-19 over a 2-month period, beginning as early as the week of diagnosis. Milk and breast swabs were analyzed for SARS-CoV-2 RNA, and milk was tested for anti-RBD IgA. SARS-CoV-2 was not detected in any milk sample or on 71% of breast swabs. Twenty-seven out of 29 (93%) breast swabs collected after breast washing tested negative for SARS-CoV-2. Detection of SARS-CoV-2 on the breast was associated with maternal coughing and other household COVID-19. Most (75%; 95% CI, 70-79%; n=316) milk samples contained anti-RBD IgA, and concentrations increased (P=.02) during the first two weeks following onset of COVID-19 symptoms or positive test. Milk-borne anti-RBD IgA persisted for at least two months in 77% of women. Milk produced by women with COVID-19 does not contain SARS-CoV-2 and is likely a lasting source of passive immunity via anti-RBD IgA. These results support recommendations encouraging lactating women to continue breastfeeding during and after COVID-19 illness.
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DOI：
10.1111/cea.12228
发表时间：
2014-01
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Järvinen KM;Westfall JE;Seppo MS;James AK;Tsuang AJ;Feustel PJ;Sampson HA;Berin C
通讯作者：
Berin C
影响因子：
5.8
作者：
Fox A;Marino J;Amanat F;Krammer F;Hahn-Holbrook J;Zolla-Pazner S;Powell RL
通讯作者：
Powell RL
影响因子：
2
作者：
Congdon JL;Kair LR;Flaherman VJ;Wood KE;LoFrumento MA;Nwaobasi-Iwuh E;Phillipi CA;Better Outcomes through Research for Newborns (BORN) Network
通讯作者：
Better Outcomes through Research for Newborns (BORN) Network
影响因子：
168.9
作者：
Chen, Huijun;Guo, Juanjuan;Zhang, Yuanzhen
通讯作者：
Zhang, Yuanzhen
影响因子：
26.1
作者：
Ronchi, Andrea;Pietrasanta, Carlo;Pugni, Lorenza
通讯作者：
Pugni, Lorenza