Breast-feeding and risk of epithelial ovarian cancer.
Breast-feeding and risk of epithelial ovarian cancer.
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DOI：
10.1007/s10552-012-9963-4
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发表时间：
2012-06
影响因子：
2.3
通讯作者：
Rossing, M. A.
中科院分区：
文献类型：
--
作者：
Jordan, S. J.;Cushing-Haugen, K. L.;Wicklund, K. G.;Doherty, J. A.;Rossing, M. A.
有证据表明，母乳喂养可能会降低上皮性卵巢癌的风险，但目前尚不清楚是否与母乳喂养的持续时间，母乳喂养的模式或卵巢癌的特定组织学亚型有关。我们试图详细调查这些问题。来自美国西部华盛顿州（2002-2007年）一项基于人群的卵巢癌研究的参与者的数据（881例病例和1，345例对照）被用来评估母乳喂养模式与卵巢癌之间的关系。Logistic回归分析计算OR值和95%可信区间。与从未母乳喂养的女性相比，母乳喂养的女性患卵巢癌的风险降低22%（OR=0.78，95%CI 0.64-0.96），并且母乳喂养的儿童的喂养时间越长，风险降低越大（平均母乳喂养时间为18个月与无母乳喂养的儿童相比，OR=0.56，95%CI 0.32-0.98）。补充饲料的引入并没有实质上改变这些影响。总体风险降低似乎最大的是类胡萝卜素和透明细胞亚型（每个母乳喂养儿童每月平均母乳喂养的OR =0.944，95%CI 0.903-0.987）。在有机会母乳喂养的妇女中，每次母乳喂养和每个母乳喂养儿童母乳喂养持续时间的增加与卵巢癌风险的降低相关，与出生次数无关，这可能对卵巢癌亚型最强。
Evidence suggests that breast feeding may decrease the risk of epithelial ovarian cancer but it is not clear whether there is a relationship with duration of breast feeding, patterns of breast feeding, or particular histological subtypes of ovarian cancer. We sought to investigate these issues in detail. Data from participants in a population-based study of ovarian cancer in western Washington State, USA (2002–2007) who had had at least one birth (881 cases and 1,345 controls) were used to assess relations between patterns of breast feeding and ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Women who ever breast fed had a 22% reduction in risk of ovarian cancer compared with those who never breast fed (OR=0.78, 95%CI 0.64–0.96) and risk reduction appeared greater with longer durations of feeding per child breast fed (OR=0.56, 95%CI 0.32–0.98 for 18 months average duration breast feeding versus none). Introduction of supplementary feeds did not substantially alter these effects. The overall risk reduction appeared greatest for the endometrioid and clear cell subtypes (OR per month of average breast feeding per child breast fed=0.944, 95%CI 0.903–0.987). Amongst women who have had the opportunity to breast feed, ever breast feeding and increasing durations of episodes of breast feeding for each breast-fed child are associated with a decrease in the risk of ovarian cancer independent of numbers of births, which may be strongest for the endometrioid subtype.
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DOI：
10.1007/s10552-009-9450-8
发表时间：
2010-02
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Titus-Ernstoff L;Rees JR;Terry KL;Cramer DW
通讯作者：
Cramer DW
影响因子：
4.7
作者：
Mills, PK;Riordan, DG;Cress, RD
通讯作者：
Cress, RD
影响因子：
2.3
作者：
Danforth, Kim N.;Tworoger, Shelley S.;Hankinson, Susan E.
通讯作者：
Hankinson, Susan E.
影响因子：
2.5
作者：
Rogers, IS
通讯作者：
Rogers, IS
影响因子：
2.3
作者：
Jordan, Susan J.;Siskind, Victor;Webb, Penelope M.
通讯作者：
Webb, Penelope M.