The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006.
The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006.
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Bisphenol A和Triclosan对美国人口免疫参数的影响，NHANES 2003-2006。
DOI：
10.1289/ehp.1002883
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发表时间：
2011-03
影响因子：
10.4
通讯作者：
Aiello AE
中科院分区：
文献类型：
--
作者：
Clayton EM;Todd M;Dowd JB;Aiello AE
暴露于环境毒物与许多疾病的结果，其中许多涉及潜在的免疫和炎症功能障碍。为了解决环境暴露与免疫功能障碍之间的差距，我们研究了两种内分泌干扰化合物（EDCs）与免疫功能标志物的关系。使用2003-2006年国家健康和营养检查调查的数据，我们比较了美国成人和6岁以上儿童的尿双酚A（BPA）和三氯生水平与血清巨细胞病毒（CMV）抗体水平以及过敏或花粉症的诊断。我们使用多变量普通最小二乘线性回归模型来研究BPA和三氯生与CMV抗体滴度的关系，并使用多变量逻辑回归模型来研究这些化学物质与过敏或花粉热诊断的关系。统计模型按年龄分层（< 18岁和≥ 18岁）。在校正了年龄、性别、种族、体重指数、肌酐水平、家庭收入和教育程度的分析中，在≥ 18岁的年龄组中，较高的尿BPA水平与较高的CMV抗体滴度相关（p < 0.001）。在< 18岁年龄组中，BPA水平较低与CMV抗体滴度较高相关（p < 0.05）。然而，三氯生，而不是BPA，显示出与过敏或花粉热诊断的正相关性。在< 18岁的年龄组中，较高水平的三氯生与被诊断为过敏或花粉热的几率更大相关（p < 0.01）。BPA和三氯生等内分泌干扰物可能会对人体免疫功能产生负面影响，分别通过CMV抗体水平和过敏或花粉热诊断来衡量，并根据年龄产生不同的后果。应进行更多的研究来调查这些发现。
Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction. To address the gap between environmental exposures and immune dysfunction, we investigated the association of two endocrine-disrupting compounds (EDCs) with markers of immune function. Using data from the 2003–2006 National Health and Nutrition Examination Survey, we compared urinary bisphenol A (BPA) and triclosan levels with serum cytomegalovirus (CMV) antibody levels and diagnosis of allergies or hay fever in U.S. adults and children ≥ 6 years of age. We used multivariate ordinary least squares linear regression models to examine the association of BPA and triclosan with CMV antibody titers, and multivariate logistic regression models to investigate the association of these chemicals with allergy or hay fever diagnosis. Statistical models were stratified by age (< 18 years and ≥ 18 years). In analyses adjusted for age, sex, race, body mass index, creatinine levels, family income, and educational attainment, in the ≥ 18-year age group, higher urinary BPA levels were associated with higher CMV antibody titers (p < 0.001). In the < 18-year age group, lower levels of BPA were associated with higher CMV antibody titers (p < 0.05). However, triclosan, but not BPA, showed a positive association with allergy or hay fever diagnosis. In the < 18-year age group, higher levels of triclosan were associated with greater odds of having been diagnosed with allergies or hay fever (p < 0.01). EDCs such as BPA and triclosan may negatively affect human immune function as measured by CMV antibody levels and allergy or hay fever diagnosis, respectively, with differential consequences based on age. Additional studies should be done to investigate these findings.
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影响因子：
5.3
作者：
Koch, Sven;Solana, Rafael;Pawelec, Graham
通讯作者：
Pawelec, Graham
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Aiello, Allison E.
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