Objective determination of optimal number of spectral-domain optical coherence tomographic images of retina to average.
Objective determination of optimal number of spectral-domain optical coherence tomographic images of retina to average.
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DOI：
10.1371/journal.pone.0110550
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sonoda S
中科院分区：
文献类型：
--
作者：
Shirasawa M;Sakamoto T;Terasaki H;Yamashita T;Uchino E;Sonoda S
通过客观方法确定为获得最清晰的视网膜图像而需要平均的最少光谱域光学相干断层成像（SD-OCT）图像数量。SD-OCT图像从9只健康眼睛和体模眼睛模型中获得。通过平均1、5、20、60和100张B扫描图像获得SD-OCT图像。在这些图像中评估不同视网膜层的反射率（平均灰度值）。通过标准差（SD）和对比度噪声比（CNR）的大小评价图像质量。还检查了由TiO 2硅胶板制成的体模眼模型。当平均图像数量从1增加到5以及从5增加到20时，SD显著降低（P <0.05，事后Tukey诚实显著差异检验）。自动真实的时间平均值为1（ART = 1）和ART = 5的SD显著大于ART = 100的SD（P <0.05）。 所有其他平均数的SD均不显著大于ART = 100的SD。 CNR随平均图像数的增加而增加，ART = 1~5和ART = 5~20之间CNR显著增加（P <0.05）。 ART = 5、ART = 20和ART = 60之间未观察到CNR的显著差异。 使用模型眼模型获得了类似的结果。虽然视网膜的SD-OCT图像的图像质量随着平均图像数量的增加而改善，但是通过平均超过20个图像，其没有显著改善。
To determine by objective methods the minimum number of spectral-domain optical coherence tomographic (SD-OCT) images to average to obtain the clearest retinal image. SD-OCT Images were obtained from 9 healthy eyes and also from a phantom eye model. The SD-OCT images were obtained by averaging 1, 5, 20, 60, and 100 B-scan images. The reflectivity (mean gray value) of the different retinal layers was evaluated in these images. The image quality was evaluated by the size of the standard deviations (SDs) and the contrast-to-noise ratios (CNRs). A phantom eye model made by TiO2 silicone plates was also examined. The SDs decreased significantly when the number of images averaged increased from 1 to 5 and also from 5 to 20 (P<0.05, post hoc Tukey's honestly significant difference tests). The SD of the automatic real time averaging of 1 (ART = 1) and ART = 5 were significantly larger than the SD of ART = 100 (P<0.05). The SDs of all other averaged numbers were not significantly larger than that of ART = 100. The CNR increased with an increase in the number of images averaged, and there was a significant increase between ART = 1 to 5 and between ART = 5 to 20 (P<0.05). No significant differences in the CNR was observed between ART = 5, ART = 20 and ART = 60. Similar results were obtained with the phantom eye model. Although the image quality of the SD-OCT images of the retina improved with an increase in the number of images averaged, it does not improve significantly by averaging more than 20 images.
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作者：
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发表时间：
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