Common immune-related risk factors and incident non-Hodgkin lymphoma: the multiethnic cohort.
Common immune-related risk factors and incident non-Hodgkin lymphoma: the multiethnic cohort.
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DOI：
10.1002/ijc.24456
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发表时间：
2009-09-15
影响因子：
6.4
通讯作者：
Kolonel LN
中科院分区：
文献类型：
--
作者：
Erber E;Lim U;Maskarinec G;Kolonel LN
严重的免疫功能障碍是淋巴瘤的一个既定的危险因素，但免疫力的中度改变的作用尚不清楚，需要前瞻性研究。我们在多种族队列中检查了与非霍奇金淋巴瘤（NHL）相关的几种免疫相关疾病和药物。1993-1996年，超过215，000名年龄在45-75岁之间的非裔美国人、高加索人、日裔美国人、拉丁美洲人和夏威夷土著血统的受试者完成了一份问卷调查，包括病史信息。排除后，我们对193,050名队列成员进行了考克斯回归分析，其中包括939例NHL病例，同时调整了性别、年龄、种族、教育、体重指数和酒精摄入量。自我报告的糖尿病总体上与NHL无关，但与日裔美国人的风险呈正相关（风险比（HR）= 1.55; 95%置信区间（CI）：1.10-2.17）。有输血史的参与者风险增加，男性HR = 1.39（95% CI：1.06-1.84），女性HR = 1.22（95% CI：0.94-1.58），尤其是弥漫性大B细胞淋巴瘤亚型。哮喘或其他过敏史仅在拉丁美洲人中与风险升高相关（HR = 1.46; 95%CI：1.07-2.00），他们也显示当前使用抗组胺药与NHL之间存在显著相关性（HR = 1.80; 95%CI：1.09-2.97）。非甾体类抗炎药的使用与NHL无关。我们从这项大型前瞻性研究中的发现支持与输血、当前长期使用抗组胺药和糖尿病相关的NHL的中度风险，但该关联仅限于某些种族群体，需要进一步重复。
Severe immune dysfunction is an established risk factor of lymphoma, but the role of moderate alterations of immunity is not clear and prospective investigations are needed. We examined several immune-related disorders and medications in relation to non-Hodgkin lymphoma (NHL) in the Multiethnic Cohort. Over 215,000 subjects of African American, Caucasian, Japanese American, Latino, and Native Hawaiian ancestry aged 45–75 years completed a questionnaire, including information on medical history, in 1993–1996. After exclusions, we performed Cox regression among 193,050 cohort members including 939 incident NHL cases while adjusting for sex, age, ethnicity, education, body mass index, and alcohol intake. Self-reported diabetes was not associated with NHL overall, but was positively associated with risk among Japanese Americans (hazard ratio (HR) = 1.55; 95% confidence interval (CI): 1.10–2.17). Participants with a history of blood transfusion were at increased risk with HR = 1.39 (95% CI: 1.06–1.84) in men and HR = 1.22 (95% CI: 0.94–1.58) in women, especially for the diffuse large B-cell lymphoma subtype. History of asthma or other allergies was associated with elevated risk only among Latinos (HR = 1.46; 95% CI: 1.07–2.00) who also showed a significant relation between current use of antihistamines and NHL (HR = 1.80; 95% CI: 1.09–2.97). Use of non-steroidal anti-inflammatory drugs was not associated with NHL. Our findings from this large prospective study support a moderate risk for NHL related to blood transfusions, current long-term antihistamine use, and diabetes, but the associations were limited to a certain ethnic groups and require further replications.
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影响因子：
2.3
作者：
Kato, I;Koenig, KL;Watanabe, H
通讯作者：
Watanabe, H
影响因子：
2.3
作者：
Hoeft, Birgit;Becker, Nikolaus;Nieters, Alexandra
通讯作者：
Nieters, Alexandra
DOI：
10.1097/00042560-199707010-00005
发表时间：
1997-07-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
影响因子：
--
作者：
Holly, EA;Lele, C
通讯作者：
Lele, C
影响因子：
5
作者：
Chao, Chun;Page, John H.
通讯作者：
Page, John H.
DOI：
10.1080/11024159850191472
发表时间：
1998-12-01
期刊：
EUROPEAN JOURNAL OF SURGERY
影响因子：
--
作者：
Gitnick, G
通讯作者：
Gitnick, G