Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development.
Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development.
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DOI：
10.3390/biom12091289
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发表时间：
2022-09-13
期刊：
影响因子：
5.5
通讯作者：
Watkins, Adam J.
中科院分区：
文献类型：
--
作者：
Batra, Vipul;Norman, Emily;Morgan, Hannah L.;Watkins, Adam J.
关键词：
作为成年人，我们的健康可能受到一系列生活方式和环境因素的影响，增加了患2型糖尿病、心脏病和肥胖症等一系列非传染性疾病的风险。在过去的几十年里，我们对成人健康如何受到出生前事件影响的理解已经发展成为一个得到充分支持的概念，即健康与疾病的发展起源（DOHaD）。在流行病学数据和实验研究的支持下，已经确定了将环境扰动、胎儿和新生儿发育中断以及成人健康不良联系起来的具体机制。最初，这些研究集中在怀孕期间产妇健康状况不佳的重要性上。然而，父亲在指导子女的发展和幸福方面的作用最近成为焦点。虽然这些研究确定了父母双方在塑造后代长期健康方面的个人作用，但很少有研究探讨父母双方对后代福祉的综合影响。这种理解是必要的，因为父母对后代发育的影响超出了精子和卵母细胞的直接遗传贡献。本文回顾了我们目前对父母对后代健康的贡献的理解，探索了一些将父母幸福与配子质量，胚胎发育和后代健康联系起来的机制。
As adults, our health can be influenced by a range of lifestyle and environmental factors, increasing the risk for developing a series of non-communicable diseases such as type 2 diabetes, heart disease and obesity. Over the past few decades, our understanding of how our adult health can be shaped by events occurring before birth has developed into a well-supported concept, the Developmental Origins of Health and Disease (DOHaD). Supported by epidemiological data and experimental studies, specific mechanisms have been defined linking environmental perturbations, disrupted fetal and neonatal development and adult ill-health. Originally, such studies focused on the significance of poor maternal health during pregnancy. However, the role of the father in directing the development and well-being of his offspring has come into recent focus. Whereas these studies identify the individual role of each parent in shaping the long-term health of their offspring, few studies have explored the combined influences of both parents on offspring well-being. Such understanding is necessary as parental influences on offspring development extend beyond the direct genetic contributions from the sperm and oocyte. This article reviews our current understanding of the parental contribution to offspring health, exploring some of the mechanisms linking parental well-being with gamete quality, embryo development and offspring health.
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