Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R.
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R.
复制标题
使用R的听觉脑干响应波形的峰值振幅和潜伏期的半自动分析。
DOI：
10.3791/64737
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发表时间：
2022-12-09
期刊：
影响因子：
--
通讯作者：
White PM
中科院分区：
文献类型：
--
作者：
Na D;White PM
过去 15 年的许多报告评估了噪声暴露等损伤后听觉脑干反应 (ABR) 波形的变化。常见的变化包括峰值 1 幅度的减小和后面峰值的相对延迟，以及中心增益的增加，这通过后面峰值的幅度与峰值 1 的幅度相比的相对增加来反映。许多实验者通过视觉识别峰值和谷值来评估它们的相对高度和延迟，当在每个频率和条件的整个听力范围内以 5 dB 增量收集波形时，这是一个费力的过程。本文描述了可以在开源平台 R 中使用 RStudio 接口执行的免费例程，以半自动测量听觉脑干反应 (ABR) 波形的波峰和波谷。这些例程识别波峰和波谷的幅度和延迟，将这些显示在生成的波形上以供检查，将结果整理并注释到电子表格中以进行统计分析，并生成图形的平均波形。如果自动化过程错误识别 ABR 波形，有一个额外的工具可以帮助纠正。目标是减少分析 ABR 波形所需的时间和精力，以便更多的研究人员将来能够进行这些分析。
Many reports in the last 15 years have assessed changes in the auditory brainstem response (ABR) waveform after insults such as noise exposure. Common changes include reductions in the peak 1 amplitude and the relative latencies of the later peaks, as well as increased central gain, which is reflected by a relative increase in the amplitudes of the later peaks compared to the amplitude of peak 1. Many experimenters identify the peaks and troughs visually to assess their relative heights and latencies, which is a laborious process when the waveforms are collected in 5 dB increments throughout the hearing range for each frequency and condition. This paper describes free routines that may be executed in the open-source platform R with the RStudio interface to semi-automate the measurements of the peaks and troughs of auditory brainstem response (ABR) waveforms. The routines identify the amplitudes and latencies of peaks and troughs, display these on a generated waveform for inspection, collate and annotate the results into a spreadsheet for statistical analysis, and generate averaged waveforms for figures. In cases when the automated process misidentifies the ABR waveform, there is an additional tool to assist in correction. The goal is to reduce the time and effort needed to analyze the ABR waveform so that more researchers will include these analyses in the future.
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